中藥材甘草成份分析

Phytochemical Studies on the Chinese medicine of Glycyrrhiza Radix.

陳志強

甘草 ； 成份分析 ； Glycyrrhiza glabra L. ； Glycyrrhiza Radix.

中原大學化學研究所學位論文

2001年

碩士

謝博進

繁體中文

摘 要 甘草(Glycyrrhiza Radix.)為豆科(Leguminosae)植物，學名(Glycyrrhiza glabra L.)，其藥理及臨床報導相當廣泛，如消化系統作用、解毒、鎮咳、抗腫瘤、泌尿生殖系統等作用。將甘草剪碎後，以95 %乙醇浸泡，過濾、減壓濃縮後得到乙醇抽出物，再以乙酸乙酯及水萃取，濃縮乙酸乙酯抽出物後以矽膠管柱色層分析、薄層色層分析等過程進行分離純化，結果得到十個化合物，經光譜資料之分析，鑑定其結構有九個屬於Flavonoids類化合物，分別為Liquiritigenin (1)，4’,5-Dihydroxy-3,7-dimethoxy flavone (2)，Licoflavonol (3)，Topazolin (4)，Formononetin (5)，Isoangustone A (6)，4,2’,4’-Trihydroxy-chalcone (8)，Isoliquiritin (9)，Isoliquiritin apioside (10)。另外，一個結構屬於Coumarin類化合物，為Glycycoumarin (7)。

Abstract The Chinese medicine of Glycyrrhiza Radix. (Glycyrrhiza glabra L.) (Leguminosae) are traditionally use as anti-inflammatory and antidiarrhea. The Chinese medicine of Glycyrrhiza Radix. were extracted with 95 % EtOH . After evaporation of the solvent, the concentrated EtOH extract was partitioned between H2O and EtOAc. By means of various column chromatographic separation , ten compounds were isolated from the EtOAc fraction. By spectral methods , nine Flavonoids including of liquiritigenin (1) , 4’,5 - dihydroxy - 3, 7 - dimethoxy flavone (2) , licoflavonol (3) , topazolin (4) , formononetin (5) , isoangustone A (6) , 4 , 2’ , 4’ - trihydroxy - chalcone (8) , isoliquiritin (9) , isoliquiritin apioside (10) . And one coumarin glycycoumarin (7) .

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