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  • 學位論文

排錢樹與血竭化學成分之研究

Studies on the Constituents of Phyllodium pulchellum and Draconis Resina

指導教授 : 陳建志 謝博進
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摘要


排錢樹,學名Phyllodium pulchellum (L.) Desv.,為豆科(Leguminosae) 排錢樹屬 (Phyllodium) 植物,以根莖葉入藥,有清熱利濕,活血祛瘀,軟堅散結之功用。本實驗以18公斤乾燥的排錢樹地上部以甲醇於50℃下萃取,甲醇萃取液濃縮後得甲醇抽出物。此甲醇抽出物以水溶解,過濾得水可溶及水不可溶兩部份,水可溶部分用正丁醇提取。正丁醇層以色層分析方法進行分離純化,得到八個純化合物,分別為兩個amines ( N,N-dimethyltryptamine (1)、5-methoxy-N,N-dimethyltryptamine (2));三個flavonoids ( citrusinol (3)、yukovanol (4)、katuranin (8))及二個新的cinnamylphenols:pulchelstyrene A (5)、pulchelstyrene E (6) ;Methyl protocatechuate (7) 。此些化合物是經由質譜及核磁共振儀的光譜分析而確認。其中化合物5及6為新化合物。血竭(Draconis Resina),為棕櫚科 (Palmae) 植物麒麟血竭Daemonorops draco Blume (Calamus draco Willd.) 及同屬他種植物果實中滲出的紅色樹脂或百合科 (Liliaceae) 植物海南龍血樹 Dracaena cambodiana Pierre ex Gagnep. 的含脂木質部提取而得的樹脂。入血分,補心包、肝血不足,活血散瘀,止血止痛,生肌斂瘡為和血之聖藥。本實驗以240 g之乾燥血竭以丙酮溶解,丙酮可溶部分以色層分析方法進行分離純化,得到五個純化合物:經光譜分析鑑定二個flavans分別為 (-)-5-methoxyflavan-7-ol (9)、 (±)-5-methoxy-6-methylflavan-7-ol (10);一個dracorhodin (11);一個新的chalcone為4,6-dihydroxy-2-methoxy-3-methyldihydrochalcone (12);一個triterpene為dammaradienol (13)。此些化合物是經由質譜及核磁共振儀的光譜分析而確認。其中化合物12為新化合物。

關鍵字

排錢樹 血竭 黃酮類 查耳酮

並列摘要


In Taiwan, Phyllodium pulchellum (L.) Desv. (Leguminosae) has been purported in folk medicine to treat fevers and liver fibrosis. The occurrence of some amines was reported previously in this plant. In the course of our continuing investigation of bioactive natural products from folk medicinal plants used in Taiwan, we investigated the constituents of the H2O-soluble portion of the MeOH extract of P. pulchellum. A combination of several chromatographic techniques led to the isolation of eight compounds, including two amines N,N-dimethyltryptamine (1) and 5-methoxy-N,N-dimethyltryptamine (2); three flavonoids citrusinol (3), yukovanol (4) and katuranin (8); two new cinnamylphenols pulchelstyrene A (5) and pulchelstyrene E (6), and Methyl protocatechuate (7). Herein the structural characterization of these eight compounds are confirmed by the spectrums of mass and NMR. Compound 5 and 6 are the new compounds of nature product. Draconis Resina, which the colophonium of the dragon tree has been purported in folk medicine to treat in hemostasis or catamenia ache. The occurrence of some flavans and flavonoids was reported previously in this plant. We investigated the constituents of the acetone-soluble portion of the acetone extract of Draconis Resina. A combination of several chromatographic techniques led to the isolation of five compounds, including two flavans (-)-5-methoxyflavan-7-ol (9) and (±)-5-methoxy-6-methylflavan-7-ol (10) one dracorhodin (11); one new chalcone 4,6-dihydroxy-2-methoxy-3-methyldihydrochalcone (12); and one triterpene dammaradienol (13). Herein the structural characterization of these five compounds are confirmed by the spectrums of mass and NMR. Compound 12 is the new compounds of nature product.

參考文獻


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