生物組織成份近紅外吸收光譜 精密量測系統

A Precision Measurement System for Near-Infrared Absorption Spectrum of Biological Tissue Constituents

陳政揚(Cheng-Yang Chen)

指導教授 ： 蔡正倫

中原大學/工學院/醫學工程研究所/碩士(2007年)

https://doi.org/10.6840/CYCU.2007.00011

摘要

準分子雷射冠狀動脈血管成形術是利用高能量雷射來消除硬化的血管斑塊，但是使用心導管的X光顯像並不容易從體外來確認雷射所治療的部位是否正確，因此若能在心導管前端利用光譜分析的方式檢測出斑塊成份，將可以省去驗證的程序，並增加雷射成形術治療的準確性。為了能夠以近紅外光反射區分出血管組織與斑塊，必須先準確地量測其主要組成成分的近紅外光吸收光譜，此研究設計製作了一個可以改變受測液體樣本厚度及控制樣本溫度的吸收光譜量測架構，以便能將光吸收度控制在0.4至1.9的最佳範圍內，來準確地測得水與脂肪酸在700nm至1700nm近紅外光光譜範圍的光吸收係數。
測量豬肉薄片樣本近紅外光反射的實驗結果顯示，當選擇脂肪酸的吸收峰(923nm、1033nm、1203nm、與1386nm)，和水的吸收峰(970nm與1180nm)進行光譜時，可以藉由計算這些近紅外光波長的光吸收度比值的改變，明顯地分辨出組織所含水與脂肪酸成份的差異。

關鍵字

近紅外吸收光譜 ； 冠狀動脈硬化 ； 準分子雷射冠狀動脈血管成形術

並列摘要

Excimer laser coronary angioplasty (ELCA) uses an optical fiber catheter to deliver high power laser energy to remove plaque in occluded arteries. Since it is difficult to use X-ray image to accurately confirm the location of plaque from outside of body, it will be helpful to develop a spectral analysis method for detecting plaque on the tip of catheter.
In order to distinguish plaque from normal vessel tissue, it is necessary to accurately measure their absorption spectra in the near-infrared region. In this study, an absorption spectrum measurement system with a variable sample path length and controllable sample temperature was built. The light absorbance can be kept at the range between 0.4 and 1.9 for measuring the absorption spectra, from 700nm to 1700nm, of water and fatty acids.
The near-infrared absorption spectrum shows fatty acids have absorption peaks at 923nm, 1033nm, 1203nm, and 1386nm and the absorption peaks of water at 970nm and 1180nm. The absorption ratios calculated from the near-infrared reflectance of a thin layer of pork sample can be used to identify its water and fat content.

並列關鍵字

Excimer laser coronary angioplasty ； Absorption spectrum

參考文獻

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