抗菌自組裝薄膜光學鏡片製程優化與性能研究

A Study of Antibacterial Self-Assembled Layers of Optics Lens

陳凱威(Kai-Wei Chen)

指導教授 ： 洪政豪

國立虎尾科技大學/工程學院/機械與機電工程研究所/碩士(2013年)

https://doi.org/10.6827/NFU.2013.00121

摘要

功能性薄膜因具有不同表面特性，於不同場合中被廣泛應用，例如疏水性薄膜、抗菌性薄膜、抗磨損薄膜等。自組裝單分子薄膜(SAMs)具有疏水特性，利用單分子自發性吸附於基材表面的特性，在基材表面形成規則且緊密排列的單分子薄膜結構，能夠有效降低材料表面的黏附特性，製作方法簡單，能廣泛應用於生醫材料、光學、電子機械、微機電工程等領域。
本文建立於混合自組裝分子薄膜技術，使用有機矽烷類的自組裝薄膜混合抗菌藥劑附著光學鏡片上，觀察薄膜親疏水特性、薄膜組成情形、抗菌能力、表面清潔度，再利用田口方法以最高接觸角度為目標，以不同浸泡溫度、烘乾溫度、藥劑濃度及浸泡時間等實驗參數，製作自組裝混合分子薄膜於光學鏡片上，得到各自組裝混合分子薄膜最佳接觸角度，OTS自組裝膜為106.3°、OTS10%抗菌混合膜為103.3°、OTS50%抗菌混合膜99.7°、ODS自組裝膜109°、ODS10%抗菌混合膜為102.1°、ODS50%抗菌混合膜為96.1°，並進行金黃葡萄球菌的抗菌檢驗，只需加入重量百分濃度10%的抗菌藥劑便能擁有極佳的抗菌效果。此外混合TEOS藥劑取得更高的接觸角度，分析薄膜表面成分，得到分子薄膜吸附與組成的影響因子，在提高接觸角度的前提之下，控制薄膜的組成情形，得到高接觸角及高清潔度之表面，TEOS接觸角度為137.8°、TEOS10%抗菌混合膜接觸角度為130.5、TEOS50%抗菌混合膜接觸角度為120.5°，ODS自組裝膜擁有最佳之透光率91.12%，且抗菌藥劑濃度增加能夠增加表面清潔度，但接觸角度有降低的現象，TEOS50%抗菌混合膜擁有高接觸角度120.5°，也擁有較佳透光率。65.77%

關鍵字

自組裝薄膜 ； 接觸角 ； 黏附力 ； 臨界負荷 ； 抗菌 ； 光學鏡片 ； 疏水性

並列摘要

Due to different surface properties, functional thin film, such as hydrophobic film, antimicrobial property film, wear resistance film, etc., is widely used in different situations. The self-assembled monomolecular film has hydrophobic properties, which can effectively reduce the adhesion property of the material’s surface through a simple production method, and can be extensively used in biomedical material, optic, electronic, machinery, micro-electro-mechanical engineering and other fields.
It is built in a mixed self-assembled molecular thin film technology, The mixed antimicrobial of the self-assembly film of the organosilane is used to adhere it onto the optics lens,, and then use the Taguchi method Exposure the highest rate of target angles, different soaking temperature, drying temperature, concentration and immersion time of the drug experimental parameters mixed self-assembled molecular thin film optical lenses, to get their films, the best mix of self-assembled molecular assembly OTS layer membrane contact surface cleanliness angle 106.3 °, 103.3 ° OTS10% antibacterial composite film, OTS50% antibacterial composite membrane 99.7 °, 102.1 ° ODS self-assembled monolayer 109 °, ODS10% antibacterial composite film, anti-bacterial film hybrid ODS50% 96.1 °, Staphylococcus aureus cocci antibacterial test, just add% (by weight) concentration of 10%, with excellent antibacterial effect, anti-bacterial. TEOS further mixed to obtain a higher membrane surface to obtain a pharmaceutical composition consisting of a film of adsorbed molecules prerequisite factor improvement control of the film composition in the case, to obtain a high contact angle and the surface contact ODS high cleanliness angle, TEOS contact angle contact angle of 137.8 °, hybrid membrane contact angle 130.5 TEOS10% antimicrobial, antibacterial TEOS50, hybrid membrane contact angle of 120.5 °, the best self-assembled monolayer optical transmittance 91.12%% , increasing concentrations of antimicrobial agent, can improve the surface cleanliness of the mixed bacterial membrane, but in the high contact angle, the contact angle of 120.5 ° to reduce TEOS50%, and has a good light transmission. 65.77%

並列關鍵字

optical lens ； self-assembled monolayer ； adhesion force ； surface forces ； contact angle ； antibacterial

參考文獻

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