An 18-year-old healthy man with marked facial and dental asymmetry due to unilateral mandibular condylar hyperplasia was treated with pre-adjusted fixed appliance therapy combined with transverse genioplasty. The total treatment time was 28 months. Although the compromised treatment did not exactly correct the asymmetry, a more-balanced proportion of facial features and a better profile were achieved. The mentalis muscle tone was also relieved, presenting a smooth labiomental fold with a satisfying outcome.