Expression of Matrix Metalloproteinases in Oral Cancer Patients Who Are Betel Quid Users

嚼食檳榔的口腔癌患者中基質金屬蛋白酶的表現

邱昶達(C. T. Chiu) ； 莊晴雅(C. Y. Chuang) ； 張松文(S. W. Chang) ； 李勝揚(S. Y. Lee) ； 王敦正(D. J. Wang) ； 劉永超(Y. C. Liu) ； 劉巡宇(S. Y. Liu) ； 顏欽堉(C. Y. Yen) ； 蔣維凡(W. F. Chang)

《臺灣口腔顎面外科學會雜誌》 19卷4期 (2008/12) Pp. 313-327

https://doi.org/10.7104/TJOMS.200812.0313

摘要

口腔癌中以鱗狀細胞癌比例最高且大多數的患者是長期的檳榔使用者，嚼食檳榔已被證實會引發口腔癌。在腫瘤侵犯與增生的過程中，基質金屬蛋白酶(MMPS)是重要的因素之一，MMPS可以重塑腫瘤周圍組織並藉由腫瘤組織、細胞外基質、發炎細胞之閒交互作用而誘導表現，藉由MMPs的高低表現可以預測腫瘤細胞的侵犯與轉移。近來陸續有研究指出MMPS的高度表現與口腔癌發生、口腔癌增生、林巴轉移及其預後有關。奇美醫學中心口腔顎面外科特別針對嚼食檳榔的口腔癌患者，研究MMPs表現與腫瘤之間的關係，發現MMP-1、-2、-3、-8、-9與-28於嚼食檳榔的口腔癌患者中有提高表現。檳榔嚼塊萃取物與檳榔素可以經由誘發MEK/ERK、P1-3K等傳遞訊號的增強以及MMPs產量增加而使以上MMPS表現增加。本篇報告是將本院口腔癌的不同組織標本中對MMPS的研究分析加以整理，並配合其他文獻報告，認同這些MMPS的表現將來可能可以成爲口腔癌腫瘤細胞的標記與預測腫瘤的預後。

關鍵字

口腔癌 ； 檳榔 ； 基質金屬蛋白酶

並列摘要

The rate of squamous cell carcinoma (SCC) is the highest among oral cancers, and most of these patients have chewed betel nuts for a long time. Betel nut chewing has been proven to cause oral cancer. During tumor invasion and proliferation, matrix metalloproteinases (MMPs) family are some of the most important factors. MMPs can remodel peripheral tissues of tumors, and their expression can be induced during interactions among tumor cells, the extracellular matrix (ECM), and inflammatory cells. Thus the up- and downregulated expressions of MMPs significantly differ when applied to predicting tumor cell invasion and transfer. The overexpression of some MMPs was associated with oral cancer occurrence, proliferation, lymph node metastasis, and prognosis in recent studies. The Department of Oral and Maxillofacial Surgery of Chi-Mei Medical Center (Tainan, Taiwan) has particularly studied MMP expressions in patient, associated with betel nut chewing. Significant increases in MMP-1, -2, -3, -8, -9, and -28 expression in oral cancer patients with betel nut chewing habit have recently been found in our studies and reported in other papers. Betel nut extract (ANE) and arecoline are known to trigger MMP expression signals based on MEK/ERK and P1-3K signal transduction expression intensities and MMP production increments. This paper collected and analysed our data of MMPs studies. Our findings show the correspondence with other researchers’ reports. We think that these MMPs can be considered to be used as oral cancer cell markers and can be used to predict cancer prognosis.

並列關鍵字

Squamous cell carcinoma ； Betel nut ； Metalloproteinases