Expression of Matrix Metalloproteinases in Oral Cancer Patients Who Are Betel Quid Users

Translated Titles





邱昶達(C. T. Chiu);莊晴雅(C. Y. Chuang);張松文(S. W. Chang);李勝揚(S. Y. Lee);王敦正(D. J. Wang);劉永超(Y. C. Liu);劉巡宇(S. Y. Liu);顏欽堉(C. Y. Yen);蔣維凡(W. F. Chang)

Key Words

口腔癌 ; 檳榔 ; 基質金屬蛋白酶 ; Squamous cell carcinoma ; Betel nut ; Metalloproteinases



Volume or Term/Year and Month of Publication

19卷4期(2008 / 12 / 01)

Page #

313 - 327

Content Language


Chinese Abstract


English Abstract

The rate of squamous cell carcinoma (SCC) is the highest among oral cancers, and most of these patients have chewed betel nuts for a long time. Betel nut chewing has been proven to cause oral cancer. During tumor invasion and proliferation, matrix metalloproteinases (MMPs) family are some of the most important factors. MMPs can remodel peripheral tissues of tumors, and their expression can be induced during interactions among tumor cells, the extracellular matrix (ECM), and inflammatory cells. Thus the up- and downregulated expressions of MMPs significantly differ when applied to predicting tumor cell invasion and transfer. The overexpression of some MMPs was associated with oral cancer occurrence, proliferation, lymph node metastasis, and prognosis in recent studies. The Department of Oral and Maxillofacial Surgery of Chi-Mei Medical Center (Tainan, Taiwan) has particularly studied MMP expressions in patient, associated with betel nut chewing. Significant increases in MMP-1, -2, -3, -8, -9, and -28 expression in oral cancer patients with betel nut chewing habit have recently been found in our studies and reported in other papers. Betel nut extract (ANE) and arecoline are known to trigger MMP expression signals based on MEK/ERK and P1-3K signal transduction expression intensities and MMP production increments. This paper collected and analysed our data of MMPs studies. Our findings show the correspondence with other researchers’ reports. We think that these MMPs can be considered to be used as oral cancer cell markers and can be used to predict cancer prognosis.

Topic Category 醫藥衛生 > 牙科與口腔科
Times Cited
  1. 邱晉儀(2006)。X光吸收光譜對氮與硼摻雜奈米鑽石薄膜之研究。淡江大學物理學系碩士班學位論文。2006。1-60。 
  2. 李怡蓁(2010)。α-水芹烯對人類肝癌細胞株之生長抑制作用。長榮大學醫學研究所學位論文。2010。1-90。 
  3. 郭志宇(2016)。聚(氮-異丙基丙烯醯胺)/聚乙烯醇衍生酸鹼/磁/熱敏感型奈米藥物載體於刺激藥物釋放之研究。臺灣大學高分子科學與工程學研究所學位論文。2016。1-206。