口腔檢體手術後縮小對癌症分期以及治療之潛在影響

Potential Underestimation of Size and T Staging Resulted from the Shrinkage of Oral Surgery Specimen

周哲宇(Tse-Yu Chou) ； 林建佑(Chien-Yu Lin) ； 張馨仁(Hsin-Jen Chang) ； 洪士涵(Shih-Han Hung)

《臺灣口腔顎面外科學會雜誌》 22卷1期 (2011/03) Pp. 1-9

https://doi.org/10.7104/TJOMS.201103.0001

摘要

簡介：原發腫瘤大小影響口腔癌之病理分期，而分期影響治療方式。口腔癌檢體取下後，於檢體處理過程可能造成病灶大小之改變，進而影響病理分期及治療。
目的：藉由口腔檢體及動物組織實驗，估計口腔癌檢體經手術及病理標本處理程序後產生之大小變化。
方法：本實驗第一部份爲記錄口腔腫瘤病患之檢體取下前後之大小變化；第二部份爲記錄豬舌浸泡福馬林及包埋切片時長度之變化。
結果：手術取下之口腔癌檢體其最大徑平均減少12.67%，豬舌檢體浸泡福馬林後其平均大小比原刻度縮小7.25%，組織切片之豬舌平均比原刻度增加5.00%。
結論：口腔檢體經標準處理後，所測得之檢體長度會縮小，使得T stage可能被低估而影響治療計畫。

關鍵字

口腔癌 ； 檢體縮小 ； 癌症分期

並列摘要

Introduction: The size of the primary lesion of oral cancer largely affects the staging and even treatment strategies. Standard pathological specimen processing may change the size of the specimen, and possibly result in different pathological staging and treatment strategy. I3ased on our study on oral surgery specimens and animal tissues, we tried to evaluate and estimate the potential size changes of oral surgery specimen during the surgery and specimen processing.
Methods: The changes of specimen size before and after surgery were recorded. The changes of specimen size during formalin fixation and histology slide processing were evaluated using an animal tissue model.
Results: The length of oral surgery specimen decreased 12.67% after surgery. The length of animal tissue decreased 7.25% after formalin fixation. The length of animal tissue increased 5.00% after histology slides were done.
Conclusion: The size of oral surgery specimen decreased after standard processing of the specimen. According to our study, the T staging of oral cancer could be underestimated under standard specimen processing, and subsequently affects the treatment strategy for the patients with oral cancer.

並列關鍵字

Oral cancer ； Specimen shrinkage ； Cancer staging