以基因微陣列比較RNA表現發現台灣引起肝膿瘍之克雷伯氏肺炎桿菌與allantoin代謝有關之特有的染色體片段

周慧琦

doi:10.6342/NTU.2004.00155

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以基因微陣列比較RNA表現發現台灣引起肝膿瘍之克雷伯氏肺炎桿菌與allantoin代謝有關之特有的染色體片段

Isolation of a Chromosomal Region Associated with Allantoin Metabolism and Liver Infection in Klebsiella pneumoniae by Microarray

周慧琦 , Ph.D　　Advisor：王錦堂　　

繁體中文 DOI： 10.6342/NTU.2004.00155

肝感染；克雷伯氏肺炎桿菌；微陣列；肝膿瘍；致病因子； microarray ； allantoin ； virulence factor ； liver abscess ； Klebsiella pneumoniae

Abstract │ Reference (76) │ Times Cited (1) │ Altmetrics

Abstract 〈TOP〉

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Klebsiella pneumoniae liver abscess with metastatic complications is an emerging infectious disease in Taiwan.  To identify genes associated with liver infection, we used a DNA microarray to compare the transcriptional profiles between three strains causing liver abscess and three strains without liver infection.  There were 14 clones that revealed higher RNA expression levels in the three liver infection strains and three of these 14 clones contained a region that was absent in MGH 78578.  The strain of K. pneumoniae MGH 78578 was isolated from a patient without liver abscess and was chosen for full genome sequencing by the Genomic Sequencing Center at Washington University (St. Louis, MO) (http//genome.wustl.edu/gsc). Sequencing of the clones revealed the replacement of 149 bp of MGH 78578 with a 21,745 bp fragment in a liver infection strain, NTUH-K2044.  This 21,745-bp fragment contained 19 open reading frames, 14 of which were proven to be associated with allantoin metabolism.  The K2044(

Reference ( 76 ) 〈TOP〉

4.Ang, S., C. Z. Lee, K. Peck, M. Sindici, U. Matrubutham, M. A. Gleeson, and J. T. Wang. 2001. Acid-induced gene expression in Helicobacter pylori: study in genomic scale by microarray. Infect. Immun. 69:1679-1686.
連結：
5.Bartlett, J. g., P. O’keefe, F. P. Tally, T. J. Louie, and S. L. Gorbach. 1986. Bacteriology of hospital-acquired pneumonia. Arch. Intern. Med. 146:868-871.
連結：
6.Benzie, I. F. F., Chung, W. Y., and B. Tomlinson. 1999. Simultaneous measurement of allantoin and urate in plasma: analytical evaluation and potential clinical application in oxidant:antioxidant balance studies. Clin. Chem. 45:901-904.
連結：
7.Boronat, A., and J. Aguilar. 1979. Rhamnose-induced propanediol oxidoreductase in Escherichia coli: purification, properities, and comparison with the fucose-induced enzyme. J. Bacteriol. 140:320-326.
連結：
8.Carpenter, J. L. 1990. Klebsiella pulmonary infections: occurrence at one medical center and review. Rev. Infect. Dis. 12:672-682.
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Times Cited (1) 〈TOP〉

鐘純珊(2009)。克雷白氏肺炎桿菌NTUH-K2044 中纖毛黏附蛋白KpfD的功能性分析。交通大學分子醫學與生物工程研究所學位論文。2009。1-54。

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