以基因微陣列比較RNA表現發現台灣引起肝膿瘍之克雷伯氏肺炎桿菌與allantoin代謝有關之特有的染色體片段

周慧琦

doi:10.6342/NTU.2004.00155

3.232.129.123，Hello！

Close
Search Quick Search Advanced Search Publication Search	Personal Service Member Login Searching History Use Bonus Card SYMSKAN
Browse Browse by University of Graduate Thesis Browse by Pinyin of Graduate Thesis Browse by Conference Proceedings Topic Browse by Conference Proceedings Publisher Browse by Pinyin of Conference Proceedings Browse by eBook Category Browse by eBook Topic Browse by eBook Publisher
Customer Services Authorize Airiti Recommend a Journal

Search Symbol (Half-width)	Description of Search Symbols
Space	"AND" indicates the intertwining of key terms used in a search
Double Quotation Marks ("") ( " " )	Double quotation marks indicate the beginning and end of a phrase, and the search will only include terms that appear in the same order of those within the quotations. Example: "image process" ： " image process "
?	Indicates a variable letter. Entering two ? will indicate two variable letters, and so on. Example: "Appl?", search results will yield apple, apply… e , appl y … ( (often used to English word searches) )
*	Indicates an unlimited number of variable letters to follow, from 1~n. Example: Enter "appl*", search results will yield apple, apples, apply, applied, application…(often used in English word searches) e , appl es , appl y , appl ied , appl ication … ( (often used to English word searches) )
AND、OR、NOT	Boolean logic combinations of key words is a skill used to expand or refine search parameters. (1) AND (1) AND: Refines search parameters (2) OR (2) OR: Expands search parameters (3) NOT: Excludes irrelevant parameters

DOI stands for Digital Object Identifier （ D igital O bject I dentifier ） ,
and is the unique identifier for objects on the internet. It can be used to create persistent link and to cite articles.

Using DOI as a persistent link

To create a persistent link, add「http://dx.doi.org/」「 http://dx.doi.org/ 」 before a DOI.
For instance, if the DOI of an article is 10.5297/ser.1201.002 , you can link persistently to the article by entering the following link in your browser: http://dx.doi.org/ 10.5297/ser.1201.002 。
The DOI link will always direct you to the most updated article page no matter how the publisher changes the document's position, avoiding errors when engaging in important research.

Cite a document with DOI

When citing references, you should also cite the DOI if the article has one. If your citation guideline does not include DOIs, you may cite the DOI link.

DOIs allow accurate citations, improve academic contents connections, and allow users to gain better experience across different platforms. Currently, there are more than 70 million DOIs registered for academic contents. If you want to understand more about DOI, please visit airiti DOI Registration （ doi.airiti.com ）。

Data Source

Health & Medical Care > Basic Medical Science
College of Medicine > Graduate Institute of Microbiology

Bibliography Management Tool

Related Links

Report an Issue

Purchase Single Articles

Download PDF

以基因微陣列比較RNA表現發現台灣引起肝膿瘍之克雷伯氏肺炎桿菌與allantoin代謝有關之特有的染色體片段

Isolation of a Chromosomal Region Associated with Allantoin Metabolism and Liver Infection in Klebsiella pneumoniae by Microarray

周慧琦 , Ph.D　　Advisor：王錦堂　　

繁體中文 DOI： 10.6342/NTU.2004.00155

肝感染；克雷伯氏肺炎桿菌；微陣列；肝膿瘍；致病因子； microarray ； allantoin ； virulence factor ； liver abscess ； Klebsiella pneumoniae

Abstract │ Reference (76) │ Times Cited (1) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

Klebsiella pneumoniae liver abscess with metastatic complications is an emerging infectious disease in Taiwan.  To identify genes associated with liver infection, we used a DNA microarray to compare the transcriptional profiles between three strains causing liver abscess and three strains without liver infection.  There were 14 clones that revealed higher RNA expression levels in the three liver infection strains and three of these 14 clones contained a region that was absent in MGH 78578.  The strain of K. pneumoniae MGH 78578 was isolated from a patient without liver abscess and was chosen for full genome sequencing by the Genomic Sequencing Center at Washington University (St. Louis, MO) (http//genome.wustl.edu/gsc). Sequencing of the clones revealed the replacement of 149 bp of MGH 78578 with a 21,745 bp fragment in a liver infection strain, NTUH-K2044.  This 21,745-bp fragment contained 19 open reading frames, 14 of which were proven to be associated with allantoin metabolism.  The K2044(

Reference ( 76 ) 〈TOP〉

4.Ang, S., C. Z. Lee, K. Peck, M. Sindici, U. Matrubutham, M. A. Gleeson, and J. T. Wang. 2001. Acid-induced gene expression in Helicobacter pylori: study in genomic scale by microarray. Infect. Immun. 69:1679-1686.
連結：
5.Bartlett, J. g., P. O’keefe, F. P. Tally, T. J. Louie, and S. L. Gorbach. 1986. Bacteriology of hospital-acquired pneumonia. Arch. Intern. Med. 146:868-871.
連結：
6.Benzie, I. F. F., Chung, W. Y., and B. Tomlinson. 1999. Simultaneous measurement of allantoin and urate in plasma: analytical evaluation and potential clinical application in oxidant:antioxidant balance studies. Clin. Chem. 45:901-904.
連結：
7.Boronat, A., and J. Aguilar. 1979. Rhamnose-induced propanediol oxidoreductase in Escherichia coli: purification, properities, and comparison with the fucose-induced enzyme. J. Bacteriol. 140:320-326.
連結：
8.Carpenter, J. L. 1990. Klebsiella pulmonary infections: occurrence at one medical center and review. Rev. Infect. Dis. 12:672-682.
連結：

Times Cited (1) 〈TOP〉

鐘純珊(2009)。克雷白氏肺炎桿菌NTUH-K2044 中纖毛黏附蛋白KpfD的功能性分析。交通大學分子醫學與生物工程研究所學位論文。2009。1-54。

Altmetrics

〈TOP〉

E-mail ：

When an article is available to download, a notice will be sent to your mailbox address.

E-mail ：