以極致液相層析/串聯式質譜儀快篩與確認多重管制藥物

楊軒緯

doi:10.6342/NTU.2012.00424

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以極致液相層析/串聯式質譜儀快篩與確認多重管制藥物

Fast Screening and Confirmation of Multiple Control Drugs Using Ultra-High Performance Liquid Chromatography/Tandem Mass Spectrometry

楊軒緯 , Masters　　Advisor：陳家揚　　

英文 DOI： 10.6342/NTU.2012.00424

管制藥物；濫用藥物；極致液相層析串聯質譜/質譜儀；電灑游離法；大氣壓光游離法；基質效應；資料庫比對； illicit drug ； abuse drug ； UHPLC-MS/MS ； electrospray ionization ； atmospheric photoionization ； matrix effect ； library search

Abstract │ Reference (56) │ Altmetrics

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The problem of drug abuse has been a long-term concern by societies, especially the increasing use on emerging drugs like tryptamines and psychedelic phenethylamines, which have not been included as control drugs. We developed a screening and confirmatory method for detecting 61 drugs including control drugs, emerging abused drugs and common combined-use drugs, with an ultra-high performance chromatography/triple-quadrupole mass spectrometer (UHPLC-QqQMS). Fifty three drugs forming positive ions were separated on an Ascentis Express RP-Amide column (50 * 2.1 mm, 2.7 μm) within 8.5 min including re-equilibrium with the mobile phase composed of acetonitrile and 10 mM ammonium acetate. The separation of eight drugs forming negative ions was achieved on a Fortis H2o column (30 * 2.1 mm, 1.7 μm) and took only 6.6 min with the mobile phase containing methanol and 0.5% acetic acid. In this study, we use antacid tablets and amoxicillin powder as the simulated matrixes; samples were extracted with sonication in methanol, then were centrifuged and filtered before injecting onto the instrument. The influence of matrix components to the ionization efficiency on 51 analytes was lower than 30%. We also compared the detection sensitivity and matrix effect between electrospray ionization (ESI) and atmospheric photoionization (APPI), and ESI was found to be better than APPI. The Chromalynx software, which was designed for fast screening of unknown compounds on a LC-time of flight-MS, was studied on the LC-QqQMS for this purpose. Retention time, analyte molecular weight, and patterns of fragmentation played crucial roles in a successful matching of library search.

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