Bracteanolide A以及龍眼花萃取物對不同肝損傷大鼠模式之預防效應

謝政橘

doi:10.6342/NTU.2015.00470

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Bracteanolide A以及龍眼花萃取物對不同肝損傷大鼠模式之預防效應

Preventive Effect of Bracteanolide A and Longan Flower Extracts on Hepatic Protection of Different Rat Liver Injury Models

謝政橘 , Ph.D　　Advisor：吳應寧　　

繁體中文 DOI： 10.6342/NTU.2015.00470

缺血再灌流損傷；龍眼花；白花水竹草；代謝症候群；果糖； Ischemia/reperfusion injury ； Longan flower ； Bracteanolide A ； Metabolic syndrome ； Fructose

Abstract │ Reference (280) │ Altmetrics

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Liver injury, which can be caused by liver surgery, liver transplantation, and diseases such as metabolic syndrome (MetS), is considered an important medical issue in Taiwan. The increasing prevalence of MetS in recent years has been tightly associated with the development of abnormal liver metabolism and hepatocellular carcinoma. Thus, our current studies focus on the protection of hepatic injury. In this study, we used proteomic approaches to investigate the preventive effects of longan flower water extract (LFWE) on high fructose (HF)-induced MetS in rats. The results show that fructose metabolism, glycolysis, lipogenesis, endoplasmic reticulum stress, inflammatory activities, fatty acid oxidation and antioxidant capacity are significantly altered in rats with MetS; however, the abnormal protein expression pattern could been rescued with LFWE supplementation. We further investigated the protective effects of longan flower ethyl acetate extract (LFEE) and Bracteanolide A pretreatment in a rat hepatic I/R injury model. The results display that both LFEE and Bracteanolide A can ameliorate I/R injury-mediated increase of aspartate aminotransferase, alanine aminotransferase, interleukin-1β, interleukin-6, interleukin-10, tumor necrosis factor-α, inducible nitric oxide synthase, and cyclooxygenase-2 activities, while at the time elevating hepatic glutathione levels after I/R injury. Histological results indicate that both LFEE and Bracteanolide A are effective in improving liver morphology during I/R injury. Therefore, LFEE and Bracteanolide A might offer a novel intervention for patients suffering from hepatic I/R injury caused by hepatectomy and liver transplantation.

Reference ( 280 ) 〈TOP〉

3. 呂文蒨。2011。以大鼠模式探討龍眼花proanthocyanidin A2的生物可利用性。博士論文。臺北：國立臺灣大學食品科技研究所。
連結：
4. 沈宜蓁。2005。龍眼花萃取物抗氧化性之探討。碩士論文。臺北：國立臺灣大學食品科技研究所。
連結：
5. 莊雅玲。2005。白花水竹草降低大鼠血中尿酸值、抗氧化性及其毒性探討。碩士論文。臺北：國立臺灣大學獸醫學研究所。
連結：
6. 黃潔妤。2009。龍眼花水萃物之乙酸乙酯區分層對高果糖誘發大鼠代謝症候群之改善功效。碩士論文。臺北：國立臺灣大學食品科技研究所。
連結：
7. 游雅茹。2012。利用細胞模式評估Bracteanolide A的抗氧化生物功能。碩士論文。臺北：國立臺灣大學食品科技研究所。
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