探討細胞核中 CTEN 參與調控 NF-κB 及 ERα 訊號反應路徑之功能

邱品慈

doi:10.6342/NTU201602533

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探討細胞核中 CTEN 參與調控 NF-κB 及 ERα 訊號反應路徑之功能

Functional relevance of nuclear CTEN in NF-κB and ERα signaling

邱品慈 , Masters　　Advisor：廖憶純　　

繁體中文 DOI： 10.6342/NTU201602533

訊號反應路徑；蛋白質交互作用；細胞凋亡；細胞增生； C-terminal tensin-like protein (CTEN) ； Nuclear-factor-kappa B (NF-κB) ； Estrogen receptor alpha (ERα)

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C-terminal tensin like (CTEN) protein, a member of tensin family, locates at focal adhesion and participates in regulation of cell adhesion, proliferation and migration. Elevated CTEN level has been detected in all stage of colon cancers. Furthermore, a high population of CTEN is located in the nucleus and interacts with α-actinin4 in colon cancer cell line, SW480. Previous studies indicated that α-actinin4 might function as a transcription factor co-activator in nuclear factor kappa B (NF-κB) and estrogen receptor α (ERα) signaling pathway in the nucleus. In this study, we investigated that whether nuclear CTEN participates in NF-κB and ERα signaling pathway to elucidate the functional role of CTEN in the nucleus. Our results have shown that knockdown of CTEN down-regulates NF-κB reporter activity and decreases the expression of TRAF-1 and IL-1β, which are NF-κB signaling pathway downstream genes. It suggests that CTEN might affect cell apoptosis and immunity in SW480 colon cancer cells. However, CTEN has no effect on TNFα-induced phosphorylation of p65, IKKβ and IκBα after TNFα stimulation. We demonstrated that CTEN does not affect p65 nuclear translocation but interacts with p65 in the nucleus. Moreover, we found that CTEN repress ERα transcriptional activity. Overexpression of CTEN decreases the expression of ERα downstream genes, PR and pS2 and inhibits cell proliferation activity in MCF-7 breast cancer cells.

Reference ( 70 ) 〈TOP〉

李昌恆 (2014) 探討 CTEN 與 β-catenin 和 α-actinin4之間的交互作用及 CTEN 於細胞核質間穿梭的機制，碩士論文，國立台灣大學生命科學院生化科技學系
Aksenova, V., Turoverova, L., Khotin, M., Magnusson, K. E., Tulchinsky, E., Melino, G., Tentler, D. (2013). Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB. Oncotarget, 4(2), 362-372.
Al-Ghamdi, S., Cachat, J., Albasri, A., Ahmed, M., Jackson, D., Zaitoun, A., Ilyas, M. (2013). C-terminal tensin-like gene functions as an oncogene and promotes cell motility in pancreatic cancer. Pancreas, 42(1), 135-140.
Albasri, A., Seth, R., Jackson, D., Benhasouna, A., Crook, S., Nateri, A. S., Ilyas, M. (2009). C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer. J Pathol, 218(1), 57-65.
Archbold, H. C., Yang, Y. X., Chen, L., & Cadigan, K. M. (2012). How do they do Wnt they do?: regulation of transcription by the Wnt/beta-catenin pathway. Acta Physiol (Oxf), 204(1), 74-109.

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