握力和癌症分期在老年癌症病人的存活分析

劉淑媛

doi:10.6342/NTU.2012.01174

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握力和癌症分期在老年癌症病人的存活分析

Survival Analysis: Handgrip Strength and Cancer Staging in the Elderly Cancer Patients

劉淑媛 , Masters　　Advisor：陳佳慧　　

繁體中文 DOI： 10.6342/NTU.2012.01174

老年人；癌症；握力；癌症分期；存活預後因子； Elderly ； cancer ； handgrip ； cancer staging ； prognostic factor for survival

Abstract │ Reference (76) │ Times Cited (1) │ Altmetrics

Abstract 〈TOP〉

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Cancer has been the first leading cause of death for the past 30 years in Taiwan. Survival is one of the most concerned issues for patients and their families. Literature has suggested that handgrip strength might be an important prognostic factor for mortality, especially in the elderly, but clinical data are limited. 
The purpose of this study was to examine the predictive power of handgrip strength in the elderly cancer population. As part of a trial study evaluating the effect of a nursing intervention on postsurgical functional decline, 95 elderly cancer patients (≧65 years) who were diagnosed with gastric and pancreatic cancer and scheduled for an abdominal surgery were enrolled from August 2007 to April 2009. Their handgrip strengths were taken prospectively at three time points: admission (preoperative baseline), discharge, and three-month after discharge. Whether handgrip strength is a prognostic factor for survival were analyzed using Cox Regression with cancer staging severed as a covariate. 
The results shown that for every 1 kg increase in preoperative handgrip strength, the all-cause mortality decreased approximately 5% (95% confidence interval 0.90 to 0.99; P<.05). This result was independent of age, gender, cancer staging, cancer types, body mass index, comorbidity, medication taken, and whether an inpatient nursing intervention was received. The findings suggested that while cancer staging remains to be the strongest prognostic factor, the preoperative handgrip strength is an independent prognostic factor for all-cause survival in the elderly cancer patients with diagnoses of gastric and pancreatic cancer. If verified, handgrip strength measure will be a simple, yet effective parameter that is clinically accessible to predict survival so treatment decisions can be well-informed and justified.

Reference ( 76 ) 〈TOP〉

潘雪幸，王桂芸 (2003)．癌症惡病質病患之護理．長庚護理雜誌，14(4)，387-395。
連結：
張欽凱，郭旭格 (2006)．衰弱症候群．長期照護雜誌， 10(3)，203-206。
連結：
葉啟娟，林明燦 (2007)．高齡者之消化道手術．臺灣醫學， 11(3)，262-266。
連結：
Abellan van Kan, G., Cameron Chumlea, W., Gillette-Guyonet, S., Houles, M., Dupuy, C., Rolland, Y., et al. (2011). Clinical trials on sarcopenia: methodological issues regarding phase 3 trials. Clinics in Geriatric Medicine, 27(3), 471-482.
連結：
Al Snih, S., Markides, K. S., Ray, L., Ostir, G. V., & Goodwin, J. S. (2002). Handgrip strength and mortality in older Mexican Americans. Journal of the American Geriatrics Society, 50(7), 1250-1256.
連結：

Times Cited (1) 〈TOP〉

蔡佩育(2013)。利用客退資料作雲端產品壽命分析－以KVM 切換器為例。臺北科技大學工業工程與管理系碩士班學位論文。2013。1-57。

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