薏苡種皮乙醇萃取物對子宮平滑肌收縮的影響

陳怡均

doi:10.6342/NTU.2010.01263

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薏苡種皮乙醇萃取物對子宮平滑肌收縮的影響

The effects on uterine smooth muscle contractions by ethanolic extract of adlay testa

陳怡均 , Masters　　Advisor：江文章　　Co-advisor ：王錫崗;夏詩閔

繁體中文 DOI： 10.6342/NTU.2010.01263

薏苡種皮；原發型經痛；前列腺素 F2α ；鈣離子移動；類黃酮； adlay testa ； primary dysmenorrhea ； PGF2α ； Ca2+ mobilization ； flavonoids

Abstract │ Reference (105) │ Times Cited (3) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

Primary dysmenorrhea is one of the common symptoms in gynecological diseases, and its high prevalence is related to the disruption in quality of female’s life. The cause of pain at the time of menses is believed to be due to the production of prostaglandin in the endometrium during ovulatory cycle. Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.), a plant of the grass crop, has long been used in traditional Chinese medicine (TCM) and also used as a nourishing food. It has also been reported to exert antiphlogistic and anodynic effects. Nevertheless, some medical reports have also suggested that adlay seeds should not be used during pregnancy. Published results have indicated that the dehulled adlay water extract (DAW) are capable of enhancing uterine contraction. In contrast, adlay hull methanolic extract (AHM) showed inhibitory effect of uterine smooth muscle contraction. Thus, the purpose of this study is to understand the effects and the action mechanisms of adlay ethanolic extracts and to confirm which compounds could regulate PGF2α-induced uterine contractions. The results demonstrate that adlay testa ethanolic extract (ATE) have an inhibitory effect on PGF2α-induced uterine contractions in rats but adlay bran ethanolic extract (ABE) and polished adlay ethanolic extract (PAE) did not. ATE-Bu-C and ATE-EA-D (100 μg/mL), subfractions of ATE-Bu and ATE-EA, decreased contractions more significantly by blocking external calcium influx. In HUtSMCs model, ATE-Bu-C and ATE-EA-D (50 μg/mL) significantly reduce the intracellular calcium concentration over 40% than control group. Furthermore, on HPLC-MS based analysis was applied. The flavonoids were quantified and posses the great inhibitory effects on uterine contractions, especially quercetin and iosliquritigenin. These present findings show the ability of ATE to inhibit PGF2α-induced uterine contractions, and have the potential to be developed as a functional food targeting primary dysmenorrhea.

Reference ( 105 ) 〈TOP〉

吳宛穎。2000。糙薏仁對第二型糖尿病病人血糖及血脂肪的影響。國立臺灣海洋
連結：
沈宜蓁。2005。龍眼花萃取物抗氧化性探討。國立臺灣大學食品科技研究所碩士
連結：
余嚴尊。2005。糙薏仁的活性區分物對倉鼠脂質代謝之研究。國立臺灣大學食品
連結：
林秀怡。2006。當專家遇見專家－經痛女性的西醫就醫經驗。高雄醫學大學性別研究所碩士論文。高雄。
連結：
高德錚，梁純玲。1986。省產薏仁品質之檢定。臺中農業改良場研究彙報 13: 11-18。
連結：

Times Cited (3) 〈TOP〉

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