轉糖鏈球菌抑制吞噬細胞毒殺作用之機轉與基因調控

陳珩昌

doi:10.6342/NTU.2006.00738

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轉糖鏈球菌抑制吞噬細胞毒殺作用之機轉與基因調控

Mechanisms and Gene Regulation Associated with Inhibition of Phagocytic Killing in Streptococcus mutans

陳珩昌 , Masters　　Advisor：賈景山　　

繁體中文 DOI： 10.6342/NTU.2006.00738

轉糖鏈球菌；吞噬細胞；毒殺；基因調控； Streptococcus mutans ； Phagocytic Killing ； Gene Regulation

Abstract │ Reference (67) │ Altmetrics

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Streptococcus mutans, being the principal etiological agent of dental caries, is also one of the most common opportunistic pathogens isolated from patients with infective endocarditis (IE). As an early step in the development of infective endocarditis, S. mutans gains access to the bloodstream from the oral cavity, and exposes in human plasma. We hypothesized that plasma as a complex medium could trigger S. mutans cells to adapt to different stresses through inducing specific gene expression upon sensing of signals from the plasma components.
    In the first part of this study, we used oligonucleotide DNA microarray to analyze the expression of the genes after plasma stimulation. We focused on the function of redox genes and one of the two component system response regulator, scnR, in this study. We found that the amino acid sequence of scnR showed 35% identify to irr response regulator, which is associated with ability against phagocytic killing in Streptococcus pyogenes. Furthermore, an isogenic scnR deletion mutant exhibited decreased ability to eliminate the reactive oxygen species (ROS) produced in Raw264.7 in comparison with wild-type S. mutans strain. In addition, plasma-induced resistance to phagocytic killing was significantly reduced in scnR deletion mutant. We hypothesize that the two component system response regulator, scnR, is important for S. mutans against phagocytic killing in Raw264.7 through stimulating redox genes expression.

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