轉糖鏈球菌抑制吞噬細胞毒殺作用之機轉與基因調控

陳珩昌

doi:10.6342/NTU.2006.00738

3.231.166.56，Hello！

Close
Search Quick Search Advanced Search Publication Search	Personal Service Member Login Searching History Use Bonus Card SYMSKAN
Browse Browse by University of Graduate Thesis Browse by Pinyin of Graduate Thesis Browse by Conference Proceedings Topic Browse by Conference Proceedings Publisher Browse by Pinyin of Conference Proceedings Browse by eBook Category Browse by eBook Topic Browse by eBook Publisher
Customer Services Authorize Airiti Recommend a Journal

Search Symbol (Half-width)	Description of Search Symbols
Space	"AND" indicates the intertwining of key terms used in a search
Double Quotation Marks ("") ( " " )	Double quotation marks indicate the beginning and end of a phrase, and the search will only include terms that appear in the same order of those within the quotations. Example: "image process" ： " image process "
?	Indicates a variable letter. Entering two ? will indicate two variable letters, and so on. Example: "Appl?", search results will yield apple, apply… e , appl y … ( (often used to English word searches) )
*	Indicates an unlimited number of variable letters to follow, from 1~n. Example: Enter "appl*", search results will yield apple, apples, apply, applied, application…(often used in English word searches) e , appl es , appl y , appl ied , appl ication … ( (often used to English word searches) )
AND、OR、NOT	Boolean logic combinations of key words is a skill used to expand or refine search parameters. (1) AND (1) AND: Refines search parameters (2) OR (2) OR: Expands search parameters (3) NOT: Excludes irrelevant parameters

DOI stands for Digital Object Identifier （ D igital O bject I dentifier ） ,
and is the unique identifier for objects on the internet. It can be used to create persistent link and to cite articles.

Using DOI as a persistent link

To create a persistent link, add「http://dx.doi.org/」「 http://dx.doi.org/ 」 before a DOI.
For instance, if the DOI of an article is 10.5297/ser.1201.002 , you can link persistently to the article by entering the following link in your browser: http://dx.doi.org/ 10.5297/ser.1201.002 。
The DOI link will always direct you to the most updated article page no matter how the publisher changes the document's position, avoiding errors when engaging in important research.

Cite a document with DOI

When citing references, you should also cite the DOI if the article has one. If your citation guideline does not include DOIs, you may cite the DOI link.

DOIs allow accurate citations, improve academic contents connections, and allow users to gain better experience across different platforms. Currently, there are more than 70 million DOIs registered for academic contents. If you want to understand more about DOI, please visit airiti DOI Registration （ doi.airiti.com ）。

Data Source

Health & Medical Care > Basic Medical Science
College of Medicine > Graduate Institute of Microbiology

Bibliography Management Tool

Related Links

Report an Issue

Purchase Single Articles

Download PDF

轉糖鏈球菌抑制吞噬細胞毒殺作用之機轉與基因調控

Mechanisms and Gene Regulation Associated with Inhibition of Phagocytic Killing in Streptococcus mutans

陳珩昌 , Masters　　Advisor：賈景山　　

繁體中文 DOI： 10.6342/NTU.2006.00738

轉糖鏈球菌；吞噬細胞；毒殺；基因調控； Streptococcus mutans ； Phagocytic Killing ； Gene Regulation

Abstract │ Reference (67) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

Streptococcus mutans, being the principal etiological agent of dental caries, is also one of the most common opportunistic pathogens isolated from patients with infective endocarditis (IE). As an early step in the development of infective endocarditis, S. mutans gains access to the bloodstream from the oral cavity, and exposes in human plasma. We hypothesized that plasma as a complex medium could trigger S. mutans cells to adapt to different stresses through inducing specific gene expression upon sensing of signals from the plasma components.
    In the first part of this study, we used oligonucleotide DNA microarray to analyze the expression of the genes after plasma stimulation. We focused on the function of redox genes and one of the two component system response regulator, scnR, in this study. We found that the amino acid sequence of scnR showed 35% identify to irr response regulator, which is associated with ability against phagocytic killing in Streptococcus pyogenes. Furthermore, an isogenic scnR deletion mutant exhibited decreased ability to eliminate the reactive oxygen species (ROS) produced in Raw264.7 in comparison with wild-type S. mutans strain. In addition, plasma-induced resistance to phagocytic killing was significantly reduced in scnR deletion mutant. We hypothesize that the two component system response regulator, scnR, is important for S. mutans against phagocytic killing in Raw264.7 through stimulating redox genes expression.

Reference ( 67 ) 〈TOP〉

3. Bernard Gu., M. D. Senadheera, G. A. Spatafora, Y. C. Huang, J. Choi, D. C. I. Hung, J. S. Treglown, S. D.Goodman, R. P. Ellen, and D. G. Cvitkovitch. 2005. A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development. J. Bacteriol. 187 (12): 4064- 4076.
連結：
4. Bisno A. L., M. O. Brito, and C. M. Collins. 2003. Molecular basis of group A streptococcal virulence. The Lancet Infectious Disease. 3 (4): 191-200.
連結：
5. Biswas S., and I. Biswas. 2006. Regulation of the glucosyltransferase (gtfBC) operon by covR in Streptococcus mutans. J. Bacteriol. 188 (3): 988-998.
連結：
6. Bogdan C., M. Roellinghoff and A. Diefenbach. 2000. Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity. Curr. Opin. Immunol. 12: 64-76.
連結：
7. Borjesson D. L., S. D. Kobayashi, A. R. Whitney, J. M. Voyich, C. M. Argue, and F. R. DeLeo. 2005. Insights into pathogen immune evasion mechanisms: Anaplasma phagocytophilum fails to induce an apoptosis differentiation program in human neutrophils. J. Immunol. 174: 6364-6372.
連結：

Altmetrics

〈TOP〉

E-mail ：

When an article is available to download, a notice will be sent to your mailbox address.

E-mail ：