轉糖鏈球菌雙分子訊息調控系統參與感染性心內膜炎的致病機轉

林奇玄

doi:10.6342/NTU.2008.01167

3.239.109.55，Hello！

Close
Search Quick Search Advanced Search Publication Search	Personal Service Member Login Searching History Use Bonus Card SYMSKAN
Browse Browse by University of Graduate Thesis Browse by Pinyin of Graduate Thesis Browse by Conference Proceedings Topic Browse by Conference Proceedings Publisher Browse by Pinyin of Conference Proceedings Browse by eBook Category Browse by eBook Topic Browse by eBook Publisher
Customer Services Authorize Airiti Recommend a Journal

Search Symbol (Half-width)	Description of Search Symbols
Space	"AND" indicates the intertwining of key terms used in a search
Double Quotation Marks ("") ( " " )	Double quotation marks indicate the beginning and end of a phrase, and the search will only include terms that appear in the same order of those within the quotations. Example: "image process" ： " image process "
?	Indicates a variable letter. Entering two ? will indicate two variable letters, and so on. Example: "Appl?", search results will yield apple, apply… e , appl y … ( (often used to English word searches) )
*	Indicates an unlimited number of variable letters to follow, from 1~n. Example: Enter "appl*", search results will yield apple, apples, apply, applied, application…(often used in English word searches) e , appl es , appl y , appl ied , appl ication … ( (often used to English word searches) )
AND、OR、NOT	Boolean logic combinations of key words is a skill used to expand or refine search parameters. (1) AND (1) AND: Refines search parameters (2) OR (2) OR: Expands search parameters (3) NOT: Excludes irrelevant parameters

DOI stands for Digital Object Identifier （ D igital O bject I dentifier ） ,
and is the unique identifier for objects on the internet. It can be used to create persistent link and to cite articles.

Using DOI as a persistent link

To create a persistent link, add「http://dx.doi.org/」「 http://dx.doi.org/ 」 before a DOI.
For instance, if the DOI of an article is 10.5297/ser.1201.002 , you can link persistently to the article by entering the following link in your browser: http://dx.doi.org/ 10.5297/ser.1201.002 。
The DOI link will always direct you to the most updated article page no matter how the publisher changes the document's position, avoiding errors when engaging in important research.

Cite a document with DOI

When citing references, you should also cite the DOI if the article has one. If your citation guideline does not include DOIs, you may cite the DOI link.

DOIs allow accurate citations, improve academic contents connections, and allow users to gain better experience across different platforms. Currently, there are more than 70 million DOIs registered for academic contents. If you want to understand more about DOI, please visit airiti DOI Registration （ doi.airiti.com ）。

Data Source

Health & Medical Care > Basic Medical Science
College of Medicine > Graduate Institute of Microbiology

Bibliography Management Tool

Related Links

Report an Issue

Purchase Single Articles

Download PDF

轉糖鏈球菌雙分子訊息調控系統參與感染性心內膜炎的致病機轉

Two component regulatory systems involved in pathogenesis of infective endocarditis by Streptococcus mutans

林奇玄 , Masters　　Advisor：賈景山　　

繁體中文 DOI： 10.6342/NTU.2008.01167

轉糖鏈球菌；感染性心內膜炎；生物膜；雙分子訊息調控系統；血小板； Streptococccus mutans ； infective endocarditis ； biofilm ； two component regulatory systems ； platelet

Abstract │ Reference (50) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

Streptococcus mutans is one of the principle causative agents of dental caries, and an opportunistic pathogen of infective endocarditis (IE). Bacteremia is caused by S. mutans following common dental procedures or oral trauma. In blood circulation, S. mutans can escape from immune surveillance and adhere on damaged valve surface to form vegetation（platelet-fibrin biofilm）, which is a decisive pathogenic process in IE. S. mutans has 14 two component systems（TCSs） which is composed of a histidine kinase sensor（HK）and a response regulator（RR）to sense and respond to environmental change. The bacterial virulence factors are commonly regulated through TCSs. We used a PCR-dependent detection assay to assess in vivo the role of individual hk or rr mutant strains potential affecting pathogenesis of IE, particularly focusing on the biofilm formation in a rat (experimental endocarditis model). One of deletion mutants rr11 was reduced in the colonization on vegetations of catheterized rats when coinfected with a pool of hk or rr mutant strains, respectively. Furthermore, we identified biofilm formation in situ on the vegetation by Ultra Sensitive Imaging System and confocal laser scanning microscope approaches. Both systems revealed that the biofilms formed by rr11 deletion mutant in the vegetation had altered architecture.  Deletion of rr11 also resulted in reduced biofilm formation in the platelet rich plasma (PRP). Together, these results indicated that the new response regulator participate in the pathogenesis of IE through regulating biofilm formation in situ on vegetation.

Reference ( 50 ) 〈TOP〉

1. Biswas I., Drake L., Erkina D., and Biswas S. 2008. Involvement of Sensor Kinases in the Stress Tolerance Response of Streptococcus mutans. J. Bacteriol., 190：68-77.
連結：
2. Biswas S., and Biswas I., 2006. Regulation of the Glucosyltransferase (gtfBC) Operon by CovR in Streptococcus mutans. J. Bacteriol., 188: 988–998
連結：
specificity of streptococci resembling Streptococcus
連結：
6. Calva E. and Oropeza R. 2006. Two-component signal transduction systems, environmental signals, and virulence. Microb. Ecol., 51：166-176.
連結：
7. Clarke J.K. 1924. On the bacterial factor in the aetiology of dental caries. Br. J. Exp. Pathol., 5:141-47.
連結：

Altmetrics

〈TOP〉

E-mail ：

When an article is available to download, a notice will be sent to your mailbox address.

E-mail ：