製備鄰苯二胺類分子用以連接酮酸醣及胜肽

Preparation of Phenylenediamine Compounds for Conjugation with Ketoacid Saccharides and Peptides

曾俊豪(Chun-Hao Tseng)

指導教授 ： 方俊民

國立臺灣大學/理學院/化學研究所/碩士(2007年)

https://doi.org/10.6342/NTU.2007.01714

摘要

無資料

關鍵字

唾液酸 ； 連接試劑 ； 喹喔啉酮 ； 疊氮苯 ； 胜肽

並列摘要

In this thesis, we plan to use a simple linker which can directly conjugate with sugar and peptide without any modification on the peptide and saccharide.

Compound 1 is the crosslinker designed for conjugation with unmodified sialic acid and peptide. Compound 1 reacted with sialic acid to give quinoxalinone derivatives 22.

Compound 26 underwent photoligation with n-butylamine to give 3H-azepine derivatives 27, and the gradual disappearance of the azido phenyl group was shown by the UV-Vis spectrum.

並列關鍵字

sialic acid ； crosslinker ； quinoxalinone ； photoligation ； peptide

參考文獻

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