果蠅蛋白質酪胺酸去磷酸酶dPTPmeg在神經肌肉接合處的發育上所扮演角色

蔡松伯

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果蠅蛋白質酪胺酸去磷酸酶dPTPmeg在神經肌肉接合處的發育上所扮演角色

The role of Drosophila PTPmeg in neuromuscular junction development

蔡松伯 , Masters　　Advisor：陳光超　　

英文

酪胺酸去磷酸酶MEG ； Src 家族激酶神經肌肉接合處；蛋白質酪氨酸去磷酸酶免疫組織化學染色； dPTPmeg ； Src ； neuromuscular junction ； protein tyrosine phosphatase ； immunohistochemistry

Abstract │ Reference (53) │ Altmetrics

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Protein tyrosine phosphatases (PTPs) are involved in the coordination of protein tyrosine kinases in various cellular processes. In Drosophila, many receptor-like protein tyrosine phosphatases(RPTPs), such as dLAR dPTP69D, and dPTP99A, are required for the development of neuromuscular junction (NMJ) but the role of non-transmembrane protein tyrosine phosphatases (NTPTPs) in NMJ development remains unknown. Recent studies have shown that one of Drosophila NTPTPs, dPTPmeg, is required for the axon projection establishment of the mushroom body. Here we studied the role of dPTPmeg in NMJ development. Gain-of-function analysis showed that dPTPmeg decreased the type Ib bouton numbers at Drosophila NMJ. However, dPTPmeg mutant does not cause obvious defects in NMJ development. We further identified Src as a dPTPmeg interacting protein. Drosophila Src has been shown to play a role in NMJ development. Genetic analysis revealed that Src knockdown could partially rescue dPTPmeg-induced NMJ defects. These findings suggest that Drosophila PTPmeg associate with Src in the regulation of NMJ development.

Reference ( 53 ) 〈TOP〉

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2.Tonks NK: Protein tyrosine phosphatases: from genes, to function, to disease. Nature reviews Molecular cell biology 2006, 7(11):833-846.
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