含少量添加物之硫酸鈣生醫陶瓷其燒結性質與生物降解行為的研究

Sintering and biodegradation behavior of calcium sulfate with a small amount of sintering additives

宗怡君(Yi-Chun Tsung)

指導教授 ： 段維新

國立臺灣大學/工學院/材料科學與工程學研究所/碩士(2013年)

https://doi.org/10.6342/NTU.2013.02667

摘要

硫酸鈣(CS)具有良好的生物相容性與可生物降解的特性，因此應用於骨替代生醫材料已行之有年。而含有SiO2-P2O5-CaO-Na2O組成結構的生物活性玻璃，能使材料與骨組織鍵結，具有刺激骨細胞分化增殖，促進新骨生成的能力。因此本實驗的目的為以硫酸鈣作基材，添加少量的燒結添加劑，如SiO2、P2O5、CaO、NaHCO3及Ag，探討其燒結行為與生物降解行為。除此之外。玻璃粉末亦當作添加劑，進一步對硫酸鈣進行改質。本實驗結果顯示，添加少量添加劑對硫酸鈣的燒結密度影響不大。此外，由微結構觀察可發現到反應相的生成，此反應相會阻礙硫酸鈣的晶粒成長。相對於未添加的純硫酸鈣陶瓷，含少量添加劑的硫酸鈣可具有較高的抗壓強度，且降解速率也有明顯的降低。整體而言，在適當的燒結環境之下，少量添加劑對於硫酸鈣的機械性質和降解行為皆有顯著的改善。故此複合材料具有良好的潛力，能在骨替代生醫陶瓷領域上有進一步的應用。

關鍵字

硫酸鈣 ； 生物活性玻璃 ； 二氧化矽 ； 燒結 ； 生物降解

並列摘要

Calcium sulfate (CS) has been used as a bone graft substitute for more than 100 years. It exhibits many desired properties as a bone substitute. These properties include biocompatible and biodegradable. The aim of the present study is to investigate the sintering and biodegradation behavior of the calcium sulfate. A small amount of sintering additives was used to improve the sinterability of CS. These additives are SiO2, P2O5, CaO, NaHCO3 and Ag. The additives are added into CS and then sintered at 1100°C. Several SiO2–CaO–P2O5–Na2O bioactive glasses exhibit excellent proliferation and differentiation for osteoblasts. They are also potential substitutes to form new bone. The glass powders were also added into CS to modify its properties.
The results demonstrate that a small amount of additives or glass affects little on the density. A reaction phase is formed; it inhibits the growth of CS grains during the sintering. The compressive strength of the specimens is increased after adding the additives. The degradation rate is slower than that of the pure CS specimens. All these results suggest that by adding a small amount of additives can improve the properties of CS. The composites investigated in the present study could be used for further application as a bone substitute.

並列關鍵字

calcium sulfate ； bioactive glass ； silica ； sintering ； biodegradation

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