腺病毒於禽流感M2疫苗發展之評估

林淑萍

doi:10.6342/NTU.2012.02902

100.24.115.215，Hello！

Close
Search Quick Search Advanced Search Publication Search	Personal Service Member Login Searching History Use Bonus Card SYMSKAN
Browse Browse by University of Graduate Thesis Browse by Pinyin of Graduate Thesis Browse by Conference Proceedings Topic Browse by Conference Proceedings Publisher Browse by Pinyin of Conference Proceedings Browse by eBook Category Browse by eBook Topic Browse by eBook Publisher
Customer Services Authorize Airiti Recommend a Journal

Search Symbol (Half-width)	Description of Search Symbols
Space	"AND" indicates the intertwining of key terms used in a search
Double Quotation Marks ("") ( " " )	Double quotation marks indicate the beginning and end of a phrase, and the search will only include terms that appear in the same order of those within the quotations. Example: "image process" ： " image process "
?	Indicates a variable letter. Entering two ? will indicate two variable letters, and so on. Example: "Appl?", search results will yield apple, apply… e , appl y … ( (often used to English word searches) )
*	Indicates an unlimited number of variable letters to follow, from 1~n. Example: Enter "appl*", search results will yield apple, apples, apply, applied, application…(often used in English word searches) e , appl es , appl y , appl ied , appl ication … ( (often used to English word searches) )
AND、OR、NOT	Boolean logic combinations of key words is a skill used to expand or refine search parameters. (1) AND (1) AND: Refines search parameters (2) OR (2) OR: Expands search parameters (3) NOT: Excludes irrelevant parameters

DOI stands for Digital Object Identifier （ D igital O bject I dentifier ） ,
and is the unique identifier for objects on the internet. It can be used to create persistent link and to cite articles.

Using DOI as a persistent link

To create a persistent link, add「http://dx.doi.org/」「 http://dx.doi.org/ 」 before a DOI.
For instance, if the DOI of an article is 10.5297/ser.1201.002 , you can link persistently to the article by entering the following link in your browser: http://dx.doi.org/ 10.5297/ser.1201.002 。
The DOI link will always direct you to the most updated article page no matter how the publisher changes the document's position, avoiding errors when engaging in important research.

Cite a document with DOI

When citing references, you should also cite the DOI if the article has one. If your citation guideline does not include DOIs, you may cite the DOI link.

DOIs allow accurate citations, improve academic contents connections, and allow users to gain better experience across different platforms. Currently, there are more than 70 million DOIs registered for academic contents. If you want to understand more about DOI, please visit airiti DOI Registration （ doi.airiti.com ）。

Data Source

School of Veterinary Medicine > Graduate Institute of Veterinary Medicine
Bio-Agriculture > Veterinary

Bibliography Management Tool

Related Links

Report an Issue

Purchase Single Articles

Download PDF

腺病毒於禽流感M2疫苗發展之評估

Evaluation of M2-based avian influenza virus vaccine using an adenovirus vector

林淑萍 , Masters　　Advisor：王金和　　Co-advisor ：鄭益謙

繁體中文 DOI： 10.6342/NTU.2012.02902

家禽流行性感冒病毒；複製缺陷腺病毒； M2 ； avian influenza virus ； replication deficient adenovirus ； M2

Abstract │ Reference (162) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

Current vaccines to avian influenza virus can’t induce broad cross-protection against different subtypes. Therefore, the purpose of this research was to develop a vaccine which can confer cross-protection by using replication-deficient adenovirus as a vector to construct a recombinant adenovirus carrying highly conserved M2 gene (Ad/M2). The immunofluorescence assay revealed positive signal in 293A and Vero cells transduced with Ad/M2. The Ad/M2 was intranasally and intramuscularly immunized in chickens twice at a 4-week interval. Anti-M2 specific antibody was significantly higher after two weeks post primary vaccination. Challenging with AIV after two weeks post boost vaccination, the consequence of real time RT-PCR revealed AIV content was no difference between Ad/M2 group and control group in oropharyngeal swab on day 4 and day 7 post challenge. The mortality of Ad/M2 group and control group was 40% and 33.3% respectively. The conclusion is giving chickens Ad/M2 couldn’t confer protection against AIV infection.

Reference ( 162 ) 〈TOP〉

Ada, G.L., Perry, B.T., 1954. The nucleic acid content of influenza virus. Aust. J. Exp. Biol. Med. Sci. 32(4), 453-468.
連結：
Alexander, D.J., 2000. A review of avian influenza in different bird species. Vet. Microbiol. 74(1-2), 3-13.
連結：
Alexander, D.J., 2008. Orthomysovirudae-avian influenza. In: Pattison, M., McMullin, P.F., Bradbury, J.M., Alexander, D.J. (Eds.), Poultry diseases, 6th ed. Elsevier, Philadelphia, PA, pp. 317-332.
連結：
Austin, F.J., Webster, R.G., 1986. Antigenic mapping of an avian H1 influenza virus haemagglutinin and interrelationships of H1 viruses from humans, pigs and birds. J. Gen. Virol. 67 ( Pt 6), 983-992.
連結：
Bakkouri, K.E., Descamps, F., De Filette, M., Smet, A., Festjens, E., Birkett, A., Van Rooijen, N., Verbeek, S., Fiers, W., Saelens, X., 2011. Universal Vaccine Based on Ectodomain of Matrix Protein 2 of Inﬂuenza A: Fc Receptors and Alveolar Macrophages Mediate Protection. J Immunol. 186(2), 1022-1031.
連結：

Altmetrics

〈TOP〉

E-mail ：

When an article is available to download, a notice will be sent to your mailbox address.

E-mail ：