- 學位論文
錐束 X 光激發光學與電腦斷層之影像系統
Cone-beam X-ray luminescence computed tomography
摘要
螢光擴散光學斷層掃描影像為新興發展的分子影像，以非侵入方式獲取體內病灶的資訊，而電腦斷層掃描影像為非常成熟的結構影像，可以提供體內組織的大小與位置，期許結合兩者各自優點，建立一個雙模態醫學影像。本研究建立一套螢光擴散光學斷層掃描系統，此系統包含一台X光發射器作為激發光光源和一台光學攝影機 (scientific Complementary Metal–Oxide–Semiconductor, sCMOS) 作為光學影像接收器，以自行撰寫的重建程式碼重建螢光光學數據配合其他合作團隊重建的電腦斷層掃描影像。已經重建六組不同假體，也包含裸鼠活體實驗，證實我們系統可以獲取小動物體內螢光影像並且可以重建螢光粒子分佈。
並列摘要
Fluorescence diffusion optical tomography is an emerging molecular imaging method that can obtain information about lesions in the body in a non-invasive way. Computed tomography imaging is a very mature structural image that can provide information on the size and location of tissues in the body. It is expected that a dual-modal medical image will be established by combining their respective advantages.In this study, a fluorescence diffusion optical tomography system was established, which consisted of an X-ray tube as the excitation light source and an optical camera , scientific Complementary Metal–Oxide–Semiconductor (sCMOS) as the optical image receiver. We reconstructed the fluorescence optical data with a self-written code, and computed tomography images reconstructed by other collaborating teams. In this paper, six groups of different prostheses have been reconstructed, including in vivo experiments in nude mice, which confirm that our system can acquire fluorescent images in small animals and reconstruct the distribution of fluorescent particles.