以貝氏模式利用條件自迴歸分布尋找甲基化誘導之變異基因

鄭璽容

doi:10.6342/NTU.2015.02942

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以貝氏模式利用條件自迴歸分布尋找甲基化誘導之變異基因

Identification of Methylation-driven Genes with Bayesian Conditional Autoregressive Model

鄭璽容 , Masters　　Advisor：蕭朱杏　　Co-advisor ：盧子彬

英文 DOI： 10.6342/NTU.2015.02942

基因表現； DNA甲基化；生物路徑；微陣列； gene expression ； DNA methylation ； pathway ； microarray

Abstract │ Reference (36) │ Altmetrics

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Multiple-platform analysis has recently become the focus of many genomic research projects. Such analysis offers an opportunity to account for the interaction between genetic observations from different platforms. Additionally, it may avoid the problems encountered in the analysis with single platform genetic markers, such as low heritability, limited information and failure in reproducing findings. 
Another problem faced in association studies is the fact that genetic data are often high-dimensional, and thus the most common approaches are single-marker tests. These tests cannot consider gene-gene interaction, and can lead to low statistical power due to corrections for multiple tests. An alternative is to consider sets of genes such as gene set-based analysis or pathway analysis. Through pathways, the knowledge as which genes participate in certain functions and how these genes interact with each other can then be used to construct the relations between genes in statistical analysis, while reserving the biological meaning at the same time. 
In this thesis, we propose a Bayesian model with a conditional autoregressive distribution to address the relations among genes in a given pathway. This model also integrates DNA methylation and RNA expression microarray data to detect influential genes. We next illustrate this Bayesian model with an ovarian cancer study. Several influential genes are identified, where some of them have been reported earlier. Finally, we discuss issues and applicability of this proposed model for genetic association studies.

Reference ( 36 ) 〈TOP〉

Baylin, S.B. and Ohm, J.E. (2006) Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction. Nat. Rev. Cancer, 6: 107–116.
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Berns, EMJJ. et al. (1996) TP53, and MYC gene alterations independently predict poor prognosis in breast cancer patients. Genes Chromosomes Cancer, 16: 170–179.
連結：
Borczuk, A.C. et al. (2004) Molecular signatures in biopsy specimens of lung cancer. Am J Respir Crit Care Med, 170: 167–174.
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Broggini, M. et al. (2000) Cell cycle-related phosphatases CDC25A and B expression correlates with survival in ovarian cancer patients. Anticancer Res, 20: 4835–4840.
連結：
Chen, Z.J. and Pikaard, C.S. (1997) Epigenetic silencing of RNA polymerase I transcription: a role for DNA methylation and histone modification in nucleolar dominance. Genes Dev, 11: 2124–2136.
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