Optical phase conjugation is an important issue in nonlinear optics and biomedical optics. We employed the pseudospectral time-domain method (PSTD) in this study to simulate the optical phase conjugation phenomenon. The research aims to simulate the different features of the reverse conjugate wave by modifying amplitude and phase. Then focus on different divergence angles and light signals. Finally, set up the biological medium as sclera and cornea cells. This study conducted a series of simulations in both above cases.