希夫式鹼配位基之鐵 (III) 錯合物的合成、結構、磁性及觸酶活性之研究

Synthesis , Structures , Magnetic properties and Catalase Activity of Iron(III) complexes with Schiff - base Ligands

陳杰妤(Chieh-Yu Chen)

指導教授 ： 魏和祥

淡江大學/理學院/化學學系碩士班/碩士(2011年)

https://doi.org/10.6846/TKU.2011.00694

摘要

本論文主要以水楊醛、胺類縮合反應合成具希夫式鹼配位基HL1~HL5，再和鐵離子反應，形成一系列的單核鐵(III) 錯合物(1)~(6)。
具希夫式鹼配位基之鐵(III) 錯合物:
(1) [Fe(HL1)Cl3]2
(2) [Fe(HL2)Cl3]．CH3CN
(3) [Fe(HL3)Cl3]．CH3CN
(4) [Fe(HL4)Cl3]2．CH3CN
(5) [Fe(HL5)Cl2(H2O)] Cl
(6) [Fe(HL4)Cl2(H2O)] Cl

L1: 2-((E)-(2-(2-(diethylamino)ethylamino)ethylimino)methyl)phenol
L2: 2-((E)-(2-(2-(diethylamino)ethylamino)ethylimino)methyl)-4-bromophenol
L3: 2-((E)-(2-(2-(diethylamino)ethylamino)ethylimino)methyl)-4-chlorophenol
L4: 2-((E)-(2-(2-(diethylamino)ethylamino)ethylimino)methyl)-4,6-dichlorophenol
L5: 2-((E)-(2-(2-(diethylamino)ethylamino)ethylimino)methyl)-4,6-dibromophenol

錯合物(1)~(6) 性質及其物性由X-ray單晶繞射儀、UV-Vis光譜、元素分析儀、電化學、電子順磁共振光譜及紅外線光譜方法來分析，並藉由SQUID變溫磁化率的測定，了解錯合物的中心金屬其磁性行為。再加入過氧化氫來了解錯合物是否有反應活性，並探討其酵素動力學。

關鍵字

希夫式鹼配位基 ； 過氧化氫酶 ； 鐵(III)錯合物

並列摘要

A seiries of mononuclear iron(Ⅲ) complexes (1) ~ (6) with Schiff - base ligands HL1~HL5 were synthesized by 2-hydroxybenzaldehyde , amine , and iron(III) chloride.
Iron(Ⅲ) complexes with Schiff – base ligands were prepared:
(1) [Fe(HL1)Cl3]2
(2) [Fe(HL2)Cl3]．CH3CN
(3) [Fe(HL3)Cl3]．CH3CN
(4) [Fe(HL4)Cl3]2．CH3CN
(5) [Fe(HL5)Cl2(H2O)] Cl
(6) [Fe(HL4)Cl2(H2O)] Cl
L1: 2-((E)-(2-(2-(diethylamino)ethylamino)ethylimino)methyl)phenol
L2: 2-((E)-(2-(2-(diethylamino)ethylamino)ethylimino)methyl)-4-bromophenol
L3: 2-((E)-(2-(2-(diethylamino)ethylamino)ethylimino)methyl)-4-chlorophenol
L4: 2-((E)-(2-(2-(diethylamino)ethylamino)ethylimino)methyl)-4,6-dichlorophenol
L5: 2-((E)-(2-(2-(diethylamino)ethylamino)ethylimino)methyl)-4,6-dibromophenol

The physical properties of complexes (1) ~ (6) were measured by X-ray Single diffraction, UV-Vis spectroscopy, infrared spectra, element analyzer, electronchemical analysises , and electron spin resonance . Magnetic susceptibilities measurements and theoretical calculations were performed to understand magnetic behavior of these complexes. Then added hydrogen peroxide to understand activity and enzyme kinetics of the mononuclear iron(Ⅲ) complexes .

並列關鍵字

Schiff - base Ligands ； Catalase ； Iron(III) complex

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