Recently, market participants are interested in the impact on the stock market resulting from investors’ sentiments gradually, but it seems that most investors are unable to make profit by using the indicators of investors’sentiments. In this study, we not only explore whether investors are able to make profits by using the investors’ sentiments, but also endeavor to exploit the favorable investment opportunities in accordance with the indicators of investors’ sentiments. Then we reveal several important findings as shown below. First, we reveal that investors had better to implement the long-term investment as the VIX index located at the low level measured by RSI technical indicators; but investors might carry out the short-term investment as the VIX index at the high level. Second, the long-term investments would be recommended as the put-call ratio located at the high level. Third, when the ratio, short-selling over margin is located at the high level, the probability of make profit would be enhanced for the short-term investment. These results revealed are rather impressive for investors, which would enhance the profitability for investing in accordance with investors’ sentiments.