幾丁聚醣選擇性接枝聚氮-異丙基丙烯醯胺的合成及其酸鹼/溫度敏感性質研究

周書仲

doi:10.6846/TKU.2007.00979

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幾丁聚醣選擇性接枝聚氮-異丙基丙烯醯胺的合成及其酸鹼/溫度敏感性質研究

Synthesis and Properties of dual-responsive copolymer hydrogels based on chitosan selectively grafted with poly(N-isopropyl acrylamide)

周書仲 , Masters　　Advisor：董崇民　　

繁體中文 DOI： 10.6846/TKU.2007.00979

幾丁聚醣；聚-氮異丙基丙烯醯胺；鄰苯二甲酸酐； chitosan ； NIPAAm ； Phthalic anhydride

Abstract │ Reference (54) │ Times Cited (3) │ Altmetrics

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In this research, phthalic anhydride(PA) was ued to react with the amino group of chitosan to protect amino group and increase chitosan solubility in organic solvent. Then 3-Isopropenyl-α,α-dimethylbenzyl isocyanate(TMI) was reacted with the hydroxyl group of PA substituted chitosan, that introduced double bond to chitosan. Subsequently hydrazine hydrate was used to remove PA and bing amino group back to CS(CS-TMI). Finnally different amounts of N-isopropylacrylamide monomer(NIPAAm) and photoinitiator were added to prepare PNIPAAm-graft-chitosan copolymers by UV irradiation.
    FTIR and NMR were used to characterize and confim the structures of PA-substitated CS and TMI-CS. From the elemental analysis, we could decide the degrees of substitution of PA as well as TMI in chitosan. The degree of TMI substitution was calculated to be 0.25. Afte UV-initiated graft polymerization of NIPAAm onto TMI-CS. We found that the conversion and grafting ratio were both inceased with increasing monomer amount. The maximum grafting ratio obtained was 3.42 and the grafting efficiency maintained at about 90％. The synthesized copolymer had dual thermal and pH-sensitive properties. DSC and TGA were employed to measure the thermal properties of the prepared copolymers. Swelling ratio was measured to understand the pH and thermal responsive behaviors. Finally, cell biocompatibility was evaluated by cell culture and MTT test on the membranes.

Reference ( 54 ) 〈TOP〉

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Allan GG, Peyron M, (1995). Molecular weight manipulation of chitosan .1.kinetics of depolymerization by nitrous acid, Carbohy Res, 277, 257,
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Alonso, I. G. , Peniche-Covas, C. and Nieto, J. M.(1983).Determinationof the degree of acetyation of chitin and chitosan by thermal analysis. J. Thermal Analysis. 28,189.
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Chatelet C, Damour O, Domard A(2001). Influence of the degree of acetylation on some Biological properties of chitosan films, Biomaterials, 22, 261
連結：
Domard, A. and Rinaudo, M. (1983). Preparation and characterization of fully deacetyllated chitosan. Int. J. Biol. Macromol, 5,49.
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