血紅素結合蛋白之基因變異型得以預測大腸直腸癌病患之存活情形

賴泓誌

doi:10.6834/CSMU.2012.00001

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血紅素結合蛋白之基因變異型得以預測大腸直腸癌病患之存活情形

Haptoglobin genotypes predict the survival of patients with colorectal cancer

賴泓誌 , Masters　　Advisor：周明智　　

繁體中文 DOI： 10.6834/CSMU.2012.00001

血紅素結合蛋白；大腸直腸癌；存活率； haptoglobin ； colorectal cancer ； survival

Abstract │ Reference (37) │ Altmetrics

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The objective of this study is to examine the correlation between genotype of haptoglobin and survival of patients with non-metastatic colorectal cancer. We evaluated cases of patients diagnosed with non-metastatic colorectal cancer at our hospital and collected blood samples. Further identification of haptoglobin genotyping based on polymerase chain reaction. From January 2005 to November 2005, totally 62 non-metastatic colorectal cancer patients was included. The patients with Hp1-1 (5 cases ) and Hp2-0 (2 cases)was not enrolled due to the small case number. Finally, 29 cases of Hp 2-1 and 27 cases of Hp 2-2 were enrolled. These patients were matched for analysis of the Hp genotype. Patients with the Hp2-2 genotype had significantly worse overall survival (Hazard ratio (HR) 3.0; p = 0.028) and disease-specific survival rates than patients with the Hp2-1 genotype (HR 3.5; p = 0.018). We demonstrated the correlation between Hp 2-2 genotype and shorter overall survival and disease-specific survival of patients with non-metastatic colorectal cancer significantly.

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