高血壓與病毒型肝炎之相關

The Association of Hypertension and Viral Hepatitis

郭秀秀(Hsiu-Hsiu Kuo)

指導教授 ： 龍嘉麒

中山醫學大學/健康管理學院/公共衛生學系碩士班/碩士(2012年)

https://doi.org/10.6834/CSMU.2012.00069

摘要

研究動機：高血壓是老年人常見的慢性病之一，長期罹患高血壓可能會導致身體免疫力衰弱，對於疾病、細菌、病毒的感受力較正常人為高。目前並無探討高血壓對於病毒性肝炎的相關風險，故本研究著重於探討高血壓對於A、B、C肝炎病毒感染的風險。

研究目的：本研究希望探討：(1)高血壓疾病盛行率；(2)高血壓群族對於A、B、C肝炎病毒的感染風險；(3)釐清自發性高血壓與高血壓性心臟病對於A、B、C肝炎病毒的感染風險是否有所不同；(4)了解老年人與一般族群（以六十五歲分層）是否在感染A、B、C肝炎病毒的風險有所差異。

研究方法：自全民健保資料庫中的100萬人中進行抽樣，針對歸人檔中的四萬人門診就診資料進行三年追蹤資料分析，估算高血壓患者對於感染病毒性肝炎的危險比。

研究結果：高血壓總人口盛行率為9.15%，45歲以上為25.15%。在控制相關干擾因子之後，發現高血壓族群罹患A型肝炎的風險較大，調整後的危險比為1.89（95% CI：1.05-3.38）；有高血壓性心臟病的族群也有較高的風險，危險比為2.05(95%CI:0.97-4.33)，但未達顯著差異。

結論：高血壓族群有較高的風險感染A型肝炎病毒。

關鍵字

高血壓 ； A型肝炎 ； B型肝炎 ； C型肝炎 ； 健保資料庫

並列摘要

Background：Hypertension is one of chronic disease, which affects in the elderly. People with hypertension frequently suffer from poor immunity, and then affected by other diseases, germs, and viruses. Up to now, study on the relationship of hepatitis infection and hypertension status is limited. In the study, we performed a cohort study to explore the risk of hepatitis A/B/C infection in patients with hypertension.
Purposes：Some aims were included in this study. The aims were to evaluate the prevalence of hypertension in study population, the risk of hepatitis A/B/C infection in patients with hypertension, and then clarify the risk of hepatitis A/B/C infection by stratified analysis for demography variables.

Materials and Methods： Taiwan Longitudinal Health Insurance Database 2005 was used to calculate the prevalence of chronic diseases. The database comprised 40,000 outpatients who have integral medical records. Patients with hypertension (N=5037) were indentified from database between January 1, 2005 and December 31, 2005, and a random sex-matched population was sampled to evaluate the risk of hepatitis A/B/C infection. Each individual was followed-up until the end of 2009. Cox proportional hazard regressions were used to evaluate the hazard ratio and multivariate regressions was adjusted for known confounding factors.

Reuslts：In Taiwan Longitudinal Health Insurance Database 2005, the prevalence of hypertension was 9.16% and the prevalence was 25.15% in population aged ≧ 45. After adjusting for potential confounders, we found that patients with hypertension were more likely to have the risk of hepatitis A infection than the compared population (HR=1.89, 95%CI: 1.05-3.38). Patients with heart disease were more likely to have the risk of hepatitis A infection (HR=2.05, 95%CI: 0.97-4.33), although it didn’t reach statistical significance.

Conclusion：As the result of the finding, patients with hypertension have higher risk in infection of hepatitis A virus than the compared population.

並列關鍵字

hypertension ； hepatitis A virus, hepatitis B virus ； hepatitis C virus ； Health Insurance Database

參考文獻

行政院衛生署國民健康局（民96）。台灣中老年身心社會生活狀況長期追

衛生署國民健康局。

晏涵文、劉潔心、鄭其嘉(民98)。台北市五專五年級學生近三十年約會

陳克誠（民96）。糖尿病會增加冠狀動脈性心臟病的死亡率 ，健康世界，8-8。

李宣緯、葉玲玲、黃達夫(民95)。台灣高血壓門診診療型態之分析探討。台灣衛誌，25(3)：201-213。