美沙冬使用者抑制缺損初探

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美沙冬使用者抑制缺損初探

Inhibitory deficits of methadone users

郭綺苑 , Masters　　Advisor：許文耀　　

繁體中文

美沙冬；注意力偏誤；彈性認知轉換；海洛因；抑制缺損； Go/No-Go ； cognition flexibility ； methadone ； heroin ； attentional bias ； inhibitory deficits ； Go/No-Go

Abstract │ Reference (73) │ Altmetrics

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The goal of this study is to explore the inhibitory deficits、attentional bias towards heroin-related cues and cognition flexibility of current methadone users. The Go/No-go task used here was previously developed by Noel et al. (2005, 2007). Heroin-related pictures and neural pictures were presented as targets or non-targets. Accuracy rate、omission、commission、average reaction time、decision bias(C) and discrimination (d’) were being measured individually. The relation between the severity of heroin dependence and task performance was also investigated.

The 17 subjects in methadone group were currently methadone maintenance treatment patients from Bali psychiatric center, and the 19 control group subjects without a drug using history were recruited by internet advertisement. The covariance analysis revealed interactions of group and shift/non-shift condition on accuracy rate、omission、decision bias(C) and discrimination (d’), indicating a cognitive flexibility deficits in methadone users. They had difficulty adapting to new rules in shifting conditions. No inhibitory deficits or attentional bias were found so far in this study.

The relation between heroin dependence and Go/No-go task performance revealed that the more dependent the methadone subjects were, the less commission errors they made, the higher decision bias score they got towards heroin pictures in non-shifting conditions. It seemed that the methadone users were prone to allocate more attention resource to heroin-related pictures in non-shifting conditions, suggesting a more selective attention process.

Reference ( 73 ) 〈TOP〉

行政院衛生署疾病管制局（2011）。替代治療月報。台北市，行政院衛生署。
連結：
行政院衛生署疾病管制局（2008）。HIV/AIDS統計月報表。台北市，行政院衛生署。
連結：
陳乃釧、楊延壽、李之徽。美沙冬替代療法。基層醫學，24(2)，61-65。
連結：
陳光輝、林自強、諶立中(2007）。海洛因成癮者之美沙酮代替療法。台灣醫學， 11(3)。
連結：
American Psychiatric Association, 2000. Diagnostic and Statistical Manual of Mental Disorders (4t ed., Text Revision; DSM-IV-TR). Washington, DC, American
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