利用PAR-2基因來提早診斷巴雷特氏食道症和其他發炎因子的相關性

陳葦瑜

doi:10.6845/NCHU.2015.00458

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利用PAR-2基因來提早診斷巴雷特氏食道症和其他發炎因子的相關性

To use PAR - 2 gene to early diagnosis of Barrett’s esophagus and other inflammatory factors Correlation.

陳葦瑜 , Masters　　Advisor：林季千　　

繁體中文 DOI： 10.6845/NCHU.2015.00458

巴雷特氏食道；蛋白酶活化受體-2 ； Barrett’s esophagus (BE) ； Protease-activated receptor -2 (PAR-2)

Abstract │ Reference (15) │ Altmetrics

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Barrett’s esophagus (BE) is precancerous condition of Esophageal Adenocarcinoma (EAC, very often deadly cancer). Every year, about 0.5% of the patients evolved from BE to Esophageal Adenocarcinoma situation. The medicine science to the BE, the patients is easily ignored when the symptom is mild, however when they need for medical treatments, the symptom often becomes serious. In terms of medical examination of the esophagus, they according to the patient described, and doctor were execute esophageal endoscopy and biopsy mainly based on clinical symptoms. The diagnosis of BE is established by endoscopic suspected esophageal metaplasia and replacement of esophageal squamous epithelium by columnar epithelium cells with goblet cells (intestinal metaplasia IM). For now, there were two methods to use endoscopic and biopsy diagnosis BE. This study was designed to compare the different expression of Protease-activated receptor -2 (PAR-2), a potential biomarker for assay the Barrett’s esophagus and EAC. Using real-time polymerase chain reaction to quantitative the PAR-2 expression in BE. We found out that the expression of PAR-2 with BE and stomach were all significantly higher than normal esophagus. By measuring cytokines include interleukin-10, interleukin-24, interleukin-3,   Cyclooxygenase-2. We can know that the patient is under the non-inflammatory period or inflammatory period. Protein activated receptor-2 protein may be a good biomarker which can be used to help us to diagnose and manage BE.

Reference ( 15 ) 〈TOP〉

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5. Song Han, Constance W. Lee, Jose G. Trevino,1 Steven J. Hughes, and George A. Sarosi, Jr Arun Rishi, Editor Autocrine Extra-Pancreatic Trypsin 3 Secretion Promotes Cell Proliferation and Survival in Esophageal Adenocarcinoma PLoS One. 2013; 8(10): e76667.
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6. Kenneth K. Wang, M.D. and Richard E. Sampliner, M.DUpdated Guidelines 2008 for the Diagnosis, Surveillance and Therapy of Barrett’s Esophagus. Am J Gastroenterol 2008;103:788–797
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