利用微流體系統包覆疏水性藥物成高分子微胞

薛成燁

doi:10.6845/NCHU.2015.00655

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利用微流體系統包覆疏水性藥物成高分子微胞

Encapsulation of hydrophobic drug in polymer micelles by microfluidic system

薛成燁 , Masters　　Advisor：蔡碩文　　

繁體中文 DOI： 10.6845/NCHU.2015.00655

高分子微胞； polymer micelles

Abstract │ Reference (55) │ Altmetrics

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The purpose of using polymer micelle technology is to miniaturize and to granulate an object so that not only its applicability and convenience can be enhanced simultaneously. Coating the different materials on micelle surface provides a new surface properties that can provide sample protection, targeted release and targeted transfer. This technique has been used in chemical industry and medical systems for many years. We developed a new microfluidic chip to capsule a hydrophobic drug by polymeric micelle and discussed its effectiveness in this study. Using the microfluidic channel system needs to consider variable conditions, including the design of structure, liquid flow rate, fluid properties and characteristics of the material. The semielliptical microfluidic chip is composed of the side injection channel, the middle injection channel and the product export channel. In this system, we injected the aqueous solution of Pluronic F127(5 %、10 %) into side channel and injected the Gliclazide of soybean oil (1 %, w/w )into middle channel. When the two solution interact, the products will be released from the product export channel. Due to the design of the cross-shaped chip, the solution of the middle channel will be pressed from both side of the channel and formed into droplets according to the effect of the laminar flow and shearing force. The surfactant of aqueous phase interacted with aqueous phase and oil phase respectively in the oil-water interface, thereby the stable droplets were produced. When the middle channel velocity is set as 0.4 μL/min and the side channel velocity is set as 0.5 mL/min, the formed droplet minimum size up to 633nm.(Pluronic F127( 5 %)) Then, we test group of the side channel flowed into Pluronic F127(10 % ). When the middle channel velocity is set as 0.4 μL/min and the side channel velocity is set as 0.8 mL/min, the formed droplet minimum size up to 101 nm. We found that double-clip flow will appear when we injected into the side channels with high flow rate. And we discovered particle size of the micelles were decreased as double-clip flow will appeared. The capsule encapsulation efficiency of target drug by high performance liquid chromatography was 70 %, and its efficiency was higher than other traditional methods.
This microfluidic system show advantage on the continuous production, reliable and can adjust the micelle’s size on demand. That can be implemented on modifying the different characteristic of the drug or function food and let it have a great uptake efficiency or sample protection capability in the future.

Reference ( 55 ) 〈TOP〉

1. Schwarze, M., et al. (2015). "Recent developments in hydrogenation and hydroformylation in surfactant systems." Catalysis Today 247: 55-63.
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2. Vroman, I. and L. Tighzert (2009). "Biodegradable Polymers." Materials 2(2): 307-344.
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3. Taha, E. I., M. M. Badran, et al. (2014). "Role of Pluronic F127 micelles in enhancing ocular delivery of ciprofloxacin." Journal of Molecular Liquids 199: 251-256.
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4. Sheykhnazari, S., T. Tabarsa, et al. (2011). "Bacterial synthesized cellulose nanofibers; Effects of growth times and culture mediums on the structural characteristics." Carbohydrate Polymers 86(3): 1187-1191.
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5. Silverberg, J. L., A. R. Barrett, et al. (2014). "Structure-Function Relations and Rigidity Percolation in the Shear Properties of Articular Cartilage." Biophysical Journal 107(7): 1721-1730.
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