氧化銅系列奈米粒子作為治療癌症光熱試劑

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氧化銅系列奈米粒子作為治療癌症光熱試劑

Copper Oxide Series Based Nanoparticles as Photothermal Agents for Cancer Therapy

許宏銘 , Masters　　Advisor：賴秉杉　　

英文

銅；金；奈米複合物；光熱治療； copper ； gold ； nanocomposites ； photothemal therapy

Abstract │ Reference (45) │ Altmetrics

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Photothermal therapy (PTT) was an innovate therapy that received many attentions due to its low invasive property. However, the vast phototheraml agents had biocompatibility problem especially copper based series agents. We focused on improvement the Cu@Cu2O stability in culture medium due to its high affinity and dissolution rate too fast that led to limitation in vitro application. Therefore, we attempted to different approaches to protect the Cu@Cu2O or Cu@Cu2O@HA modification on that NPs surface. However, these approach was modified to the Cu@Cu2O or Cu@Cu2O, the stability no obviously was improved. Eventually, we directly added another metal to reform the bimetallic nanocomposites (NCs). In addition, The Cu-Au bimetallic NCs exhibited excellent photothermal performance that remain original similar photothermal property due to their strong near-infrared (NIR) absorption property. The size of Cu-Au bimetallic NCs detected by TEM about 10 nm and this size could through passive targeting due to enhance permeability and retention (EPR) effect. Moreover, improvement stability in culture medium of the Cu-Au bimetallic NCs. In vitro experiment indicated Cu-Au bimetallic NCs without 808 nm laser irradiation reveal low cytotoxicity, whereas, the almost 20% cells survival with laser irradiation in cancer cells. Consequently, the bimetallic NCs not only possessed excellent photothemral efficiency but increase biocompatibility via reducing the copper ions release in biomedical application.

Reference ( 45 ) 〈TOP〉

[2] Kobayashi H, Watanabe R, Choyke PL. Improving conventional enhanced permeability and retention (EPR) effects; what is the appropriate target? Theranostics. 2013;4:81-9.
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[3] Fang J, Chen YC. Nanomaterials for Photohyperthermia: A Review. Curr Pharm Design. 2013;19:6622-34.
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[6] Melamed JR, Edelstein RS, Day ES. Elucidating the Fundamental Mechanisms of Cell Death Triggered by Photothermal Therapy. ACS Nano. 2015;9:6-11.
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[7] Govorov AO, Richardson HH. Generating heat with metal nanoparticles. Nano Today. 2007;2:30-8.
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