苦茶油之免疫調節及抗發炎功效

林佳瑩

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苦茶油之免疫調節及抗發炎功效

Immunomodulatory and anti-inflammatory effects of camellia oil

林佳瑩 , Masters　　Advisor：顏國欽　　

繁體中文

苦茶油；初代細胞；抗發炎；免疫調節；體液免疫； Camellia oil ； primary cell ； anti-inflammation ； immunomodulatory ； humoral immunity

Abstract │ Reference (108) │ Altmetrics

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The beneficial effects of Camellia oil (Camellia oleifera Abel.) on gastrointestinal tract have been recognized; however, the effect of camellia oil on immunomodulatory has not been studied. Therefore, the aim of this study was to evaluate the immunomodulatory effects of camellia oil using an in vitro and in vivo models. In vitro, the results showed that RAW 264.7 macrophage treated with camellia oil (more than 25 &micro;g/mL) significantly increased the phagocytosis activity, and reduced the productions of inflammatory cytokines, including NO, IFN-γ and IL-6. Treatment with camellia oil H (more than 25 &micro;g/mL) significantly increased the proliferation to splenocytes and the phagocytosis activity of macrophage, and reduced the productions of inflammatory cytokines, including NO (with lipopolysaccharide), IL-1β and IFN-γ (with concanavalin A) from splenocytes, and increased the productions of anti-inflammatory cytokines, including IL-10 and IL-4 (camellia oil more than 50 &micro;g/mL and with Con A stimulated) from splenocytes, and reduced the production of inflammatory cytokines, including NO, IL-1β (with LPS) and IFN-γ from Peyer’s Patches. In addition, camellia oil could promote the immune regulation toward CD19+ humoral immune response. In vivo, the results showed that oral gavage of BALB/c mice with camellia oil H and L (2 mL/Kg) for 21 days, not only significantly increased the proliferation of splenocytes and the productions of anti-inflammatory cytokines, including IL-10 and IL-4 (with LPS or ConA), and also reduced the production of inflammatory cytokines, including IFN-γ (with LPS) and NO (with LPS). Moreover, camellia oil induced the splenocytes toward humoral and cellular (with ConA) immunity at the same time. In conclusion, camellia oil has the potential to enhance immune function, including increased the phagocytosis by macrophages, humoral immunity and cellular immunity. Camellia oil also could modulate the Th1/Th2 cytokines production, suggesting that this agent can be used for modulation of the immune system and as anti-inflammatory agent. The best effect of camellia oil on immunomodulatory is camellia oil with the concentration of 200 and 400 μg/mL in vitro. Therefore, our results support the possible use of camellia oil as a dietary supplement toward immunomodulation.

Reference ( 108 ) 〈TOP〉

尹華文、呂勝由等，苦茶油、茶籽油與茶樹精油之辨別、萃取及其利用。林業研究專訊 Vol.17 No.4 2010。
連結：
王振瀾、林玉含，優良品種油茶油脂成分的提煉及性質分析。林業試驗所研究報告季刊，1990，5：11-15。
連結：
杜邦碩，苦茶油對乙醇誘導小鼠急性腸胃黏膜損傷之保護效應。國立中興大學食品暨應用生物科技學系碩士論文，2016。
連結：
謝志享，以初代免疫細胞培養評估不同食材之免疫調節傾向並探討桑椹多醣對卵白蛋白致敏小鼠之免疫調節功能。國立中興大學食品暨應用生物科技學系碩士論文，2007。
連結：
Abautret-Daly, A.; Dempsey, E.; Parra-Blanco, A.; Medina, C.; Harkin, A., Gut-brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease. Acta Neuropsychiatr 2017, 1-22.
連結：

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