樟芝菌絲體醣蛋白Antrodan合併順鉑在小鼠異體移植肺癌細胞株(LLC1)之模式中抑制腫瘤轉移並改善順鉑的腎毒性

陳佩君

doi:10.6845/NCHU.2015.01019

3.236.231.14，Hello！

Close
Search Quick Search Advanced Search Publication Search	Personal Service Member Login Searching History Use Bonus Card SYMSKAN
Browse Browse by University of Graduate Thesis Browse by Pinyin of Graduate Thesis Browse by Conference Proceedings Topic Browse by Conference Proceedings Publisher Browse by Pinyin of Conference Proceedings Browse by eBook Category Browse by eBook Topic Browse by eBook Publisher
Customer Services Authorize Airiti Recommend a Journal

Search Symbol (Half-width)	Description of Search Symbols
Space	"AND" indicates the intertwining of key terms used in a search
Double Quotation Marks ("") ( " " )	Double quotation marks indicate the beginning and end of a phrase, and the search will only include terms that appear in the same order of those within the quotations. Example: "image process" ： " image process "
?	Indicates a variable letter. Entering two ? will indicate two variable letters, and so on. Example: "Appl?", search results will yield apple, apply… e , appl y … ( (often used to English word searches) )
*	Indicates an unlimited number of variable letters to follow, from 1~n. Example: Enter "appl*", search results will yield apple, apples, apply, applied, application…(often used in English word searches) e , appl es , appl y , appl ied , appl ication … ( (often used to English word searches) )
AND、OR、NOT	Boolean logic combinations of key words is a skill used to expand or refine search parameters. (1) AND (1) AND: Refines search parameters (2) OR (2) OR: Expands search parameters (3) NOT: Excludes irrelevant parameters

DOI stands for Digital Object Identifier （ D igital O bject I dentifier ） ,
and is the unique identifier for objects on the internet. It can be used to create persistent link and to cite articles.

Using DOI as a persistent link

To create a persistent link, add「http://dx.doi.org/」「 http://dx.doi.org/ 」 before a DOI.
For instance, if the DOI of an article is 10.5297/ser.1201.002 , you can link persistently to the article by entering the following link in your browser: http://dx.doi.org/ 10.5297/ser.1201.002 。
The DOI link will always direct you to the most updated article page no matter how the publisher changes the document's position, avoiding errors when engaging in important research.

Cite a document with DOI

When citing references, you should also cite the DOI if the article has one. If your citation guideline does not include DOIs, you may cite the DOI link.

DOIs allow accurate citations, improve academic contents connections, and allow users to gain better experience across different platforms. Currently, there are more than 70 million DOIs registered for academic contents. If you want to understand more about DOI, please visit airiti DOI Registration （ doi.airiti.com ）。

Data Source

College of Agriculture and Natural Resourses > Department of Food Science and Biotechnology
Bio-Agriculture > Biological Science

Bibliography Management Tool

Related Links

Report an Issue

Purchase Single Articles

Download PDF

樟芝菌絲體醣蛋白Antrodan合併順鉑在小鼠異體移植肺癌細胞株(LLC1)之模式中抑制腫瘤轉移並改善順鉑的腎毒性

Antrodan, a glycoprotein isolated from Antrodia cinnamomea mycelia, in combination with cisplatin inhibits tumor metastasis and protects against cisplatin-induced nephrotoxicity in C57BL/6 mice xenografted with Lewis lung carcinoma

陳佩君 , Masters　　Advisor：胡淼琳　　Co-advisor ：喬長誠

繁體中文 DOI： 10.6845/NCHU.2015.01019

樟芝菌絲體醣蛋白；癌轉移；順鉑；小鼠肺癌細胞； Antrodan ； Metastasis ； Cisplatin ； Lewis Lung carcinoma

Abstract │ Reference (49) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

Antrodia cinnamomea is a species known to be a treasured medicinal mushroom in Taiwan. Several studies have indicated that Antrodan, the glycoprotein from Antrodia cinnamomea mycelia, exhibits anti-inflammation and anti-oxidative actions. In addition, Antrodan has been shown to inhibit cancer metastasis in Lewis lung carcinoma (LLC) through direct action and immunomodulation. However, it is still unclear whether Antrodan has anti-metastatic effects in vivo. This study aimed to investigate the anti-metastatic effects of Antrodan and Antrodan in combination with  cisplatin and to explore the protective effects of Antrodan against cisplatin-induced nephrotoxicity using tumor xenografted mice. LLC were injected (s.c.) into to C57BL/6 mice for 9 days, and mice were administered with Antrodan (20 and 40 mg/kg; p.o.) daily, cisplatin (1 mg/kg; i.p.) twice per week or their combined treatment for an additional 28 days. Results reveal that Antrodan treatment significantly (1) inhibited the number of tumor metastasis in lung and liver tissues and primary tumor growth; (2) decreased activities of urokinase-type plasminogen activator, matrix metalloproteinase (MMP)-2 and -9 in plasma; (3) reduced MMP-2/9 protein expression of and phosphorylation of signal transducer and activator of transcription 3 (STAT3) and mitogen-activated protein kinase (MAPK), including extracellular regulated protein kinases (ERK), c-Jun N-terminal kinase (JNK) and p38 in lung and liver tissues; (4) decreased plasma interleukin-6 level and increased interferon-γ level. Cisplatin exhibited similar inhibitory effects, except for the number of tumor metastasis in lung tissues. The combined treatment exhibited additive action on inhibition of primary tumor growth, plasma MMP-9 activity, and protein expression of MMP-2 and MMP-9 in lung and liver tissues. In addition, Antrodan effectively improved cisplatin-induced nephtotoxicity, as evidenced by decreased cisplatin-induced blood urea nitrogen levels in plasma and p38 phosphorylation in kidney. Overall, the present results demonstrate that Antrodan has abilities to inhibit cancer metastasis and to improve nephrotoxicity induced by cisplatin in vivo.

Reference ( 49 ) 〈TOP〉

2. Herbst R, Heymach J, Lippman S. (2002). Lung cancer. N Engl J Med. 359(13):1367–80.
連結：
3. Okuno, S. H., & Jett, J. R. (2002). Small cell lung cancer: current therapy and promising new regimens. The Oncologist, 7(3), 234-238.
連結：
4. D'addario, G., Früh, M., Reck, M., Baumann, P., Klepetko, W., Felip, E., & ESMO Guidelines Working Group. (2010). Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 21(suppl 5), v116-v119.
連結：
5. Beadsmoore, C. J., & Screaton, N. J. (2003). Classification, staging and prognosis of lung cancer. European journal of radiology, 45(1), 8-17.
連結：
6. Jackman, D. M., & Johnson, B. E. (2005). Small-cell lung cancer. The Lancet, 366(9494), 1385-1396.
連結：

Altmetrics

〈TOP〉

E-mail ：

When an article is available to download, a notice will be sent to your mailbox address.

E-mail ：