發炎對體內維生素B6代謝的影響

侯慧卿

3.236.156.34，Hello！

Close
Search Quick Search Advanced Search Publication Search	Personal Service Member Login Searching History Use Bonus Card SYMSKAN
Browse Browse by University of Graduate Thesis Browse by Pinyin of Graduate Thesis Browse by Conference Proceedings Topic Browse by Conference Proceedings Publisher Browse by Pinyin of Conference Proceedings Browse by eBook Category Browse by eBook Topic Browse by eBook Publisher
Customer Services Authorize Airiti Recommend a Journal

Search Symbol (Half-width)	Description of Search Symbols
Space	"AND" indicates the intertwining of key terms used in a search
Double Quotation Marks ("") ( " " )	Double quotation marks indicate the beginning and end of a phrase, and the search will only include terms that appear in the same order of those within the quotations. Example: "image process" ： " image process "
?	Indicates a variable letter. Entering two ? will indicate two variable letters, and so on. Example: "Appl?", search results will yield apple, apply… e , appl y … ( (often used to English word searches) )
*	Indicates an unlimited number of variable letters to follow, from 1~n. Example: Enter "appl*", search results will yield apple, apples, apply, applied, application…(often used in English word searches) e , appl es , appl y , appl ied , appl ication … ( (often used to English word searches) )
AND、OR、NOT	Boolean logic combinations of key words is a skill used to expand or refine search parameters. (1) AND (1) AND: Refines search parameters (2) OR (2) OR: Expands search parameters (3) NOT: Excludes irrelevant parameters

DOI stands for Digital Object Identifier （ D igital O bject I dentifier ） ,
and is the unique identifier for objects on the internet. It can be used to create persistent link and to cite articles.

Using DOI as a persistent link

To create a persistent link, add「http://dx.doi.org/」「 http://dx.doi.org/ 」 before a DOI.
For instance, if the DOI of an article is 10.5297/ser.1201.002 , you can link persistently to the article by entering the following link in your browser: http://dx.doi.org/ 10.5297/ser.1201.002 。
The DOI link will always direct you to the most updated article page no matter how the publisher changes the document's position, avoiding errors when engaging in important research.

Cite a document with DOI

When citing references, you should also cite the DOI if the article has one. If your citation guideline does not include DOIs, you may cite the DOI link.

DOIs allow accurate citations, improve academic contents connections, and allow users to gain better experience across different platforms. Currently, there are more than 70 million DOIs registered for academic contents. If you want to understand more about DOI, please visit airiti DOI Registration （ doi.airiti.com ）。

Data Source

College of Agriculture and Natural Resourses > Department of Food Science and Biotechnology
Bio-Agriculture > Biological Science

Bibliography Management Tool

Related Links

Report an Issue

Search in Library

There is no full-text available at the moment. Airiti would like to request author's authorization. I would like to provide authorization.

發炎對體內維生素B6代謝的影響

Inflammation alters vitamin B6 metabolism in vivo.

侯慧卿 , Masters　　Advisor：蔣恩沛　　

英文

類風濕性關節炎；維生素B6 ；磷酸比哆醛；發炎；比哆酸； Rheumatoid arthritis ； vitamin B6 ； pyridoxal 5’-phsophate ； inflammation ； 4-pyridoxic acid

Abstract │ Reference (108) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

Abstract
Rheumatoid arthritis (RA) is a systemic autoimmune disease with unclear etiology and pathogenesis. Pyridoxal 5’-phosphate (PLP) is the major B6 vitamins form, and a variety of disease conditions have repeatedly been found to be associated with low levels of plasma PLP. Inverse associations have been shown between plasma PLP and biomarkers of human inflammation.  Collagen-induced arthritis (CIA) and adjuvant-induced arthritis (AA) rats are commonly used as models for studying human with rheumatoid arthritis (RA). The objective of the present study is to investigate vitamin B6 metabolism during inflammation in vivo. Twenty-two 6-week-old female Lewis rats were housed in individual IVC cages under pathogen-free condition on a 12-hour day/night cycle and fed with the AIN93M diet during the experimental period.  Arthritis was induced at the age of 10-week and were sacrificed at the age of 15-weeks during chronic inflammation. The volume of paw significantly increased in both AA and CIA groups during inflammation while body weight significantly decreased. Arthritis induction did not alter 24-hour urinary excretion of vitamin B6 in both models. However, inflammation resulted in drastic alterations in vitamin B6 in both liver and certain extra-hepatic tissues except for the spleen.  The lower circulating plasma PLP levels observed in the CIA group reflected a decrease in hepatic PLP contents, as a positive correlation was observed between the two (r=0.731 p=0.039, n=8).  The mechanism by which arthritis causes vitamin B6 mobilization during inflammation is under investigation.

Reference ( 108 ) 〈TOP〉

Reference List
連結：
1. Lamers Y. Indicators and methods for folate, vitamin B-12, and vitamin B-6 status assessment in humans. Curr.Opin.Clin.Nutr.Metab Care 2011;14(5)445-454.
連結：
2. Tully DB, Allgood VE, Cidlowski JA. Modulation of steroid receptor-mediated gene expression by vitamin B6. FASEB J. 1994;8(3)343-349.
連結：
3. Said HM, Ortiz A, Vaziri ND. Mechanism and regulation of vitamin B(6) uptake by renal tubular epithelia: studies with cultured OK cells. Am.J.Physiol Renal Physiol 2002;282(3)F465-F471.
連結：
4. Wu XY, Lu L. Vitamin B6 deficiency, genome instability and cancer. Asian Pac.J.Cancer Prev. 2012;13(11)5333-5338.
連結：

Altmetrics

〈TOP〉

E-mail ：

When an article is available to download, a notice will be sent to your mailbox address.

E-mail ：