開發多孔性聚乳酸微粒作為軟組織填補劑之應用

黃曼婷

doi:10.6841/NTUT.2013.00095

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開發多孔性聚乳酸微粒作為軟組織填補劑之應用

Development of porous polylactic acid for the soft tissue filling applications

黃曼婷 , Masters　　Advisor：方旭偉　　

繁體中文 DOI： 10.6841/NTUT.2013.00095

聚乳酸；生物可分解性；生物相容性；填充劑；脂肪幹細胞； Polylactic acid ； Biodegradable ； Biocompatible ； Filler ； Adipose-Derived Stem Cell

Abstract │ Reference (44) │ Times Cited (1) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

The experimental research for the development of porous polylactic acid as a dermal stimulant, the main mechanism is implanted biomaterials by inducing inflammation, so that fibroblasts close, and then secrete collagen, reaching the dermis proliferation purposes. In addition to filling effect can be achieved, and can be extended to fill the prescription.Because of its biodegradable, bioabsorbable and biocompatible nature, has been widely used in biomaterial applications. Use of polylactic acid, the development of
porous particles, while establishing a porous polylactic acid particle processes, complete determination of the nature and identify the best conditions, the material on cytotoxicity detection. Polylactic acid with a gel-forming injectable soft tissue filling agent is injected into the body to fill the necessary parts, such as fold part.
Currently on the market, often with hydroxyapatite and polylactic acid, etc. The problem is that the existing shortcomings material fabrication process, it is different
particle size, surface morphology and the material in the filling material irregularities within the dispersion is not well, resulting in uneven dermal irritation, locally
excessive reaction, clinical phenomena such as pimples and granulation tissue swelling. To enhance the application, obtained through the process of polylactic acid particles porous filling material made with the development of the brand-Sculptra listed for comparison, for example: the appearance, viscoelasticity, dispersion and so on. Finally, the selected adipose stem cells and polylactide porous filling material mixed, testing biocompatibility.
Therefore, the purpose of the experiment is to develop a uniform size of the porous morphology of polylactic acid particles to improve the existing dermal stimulation uneven fill effects, and optimizing fill formulations, the effect of the natural softness.

Reference ( 44 ) 〈TOP〉

1. Dastoor, S.F., C.E. Misch, and H.-L. Wang, "Dermal Fillers for Facial Soft Tissue Augmentation," Journal of Oral Implantology, vol. 33, no. 4, 2007, pp.191-204.
連結：
2. Klein, A.W. and M.L. Elson, "The History of Substances for Soft Tissue Augmentation," Dermatologic Surgery, vol. 26, no.12, 2000, pp. 1096-1105.
連結：
3. Griffey, S., N.D. Schwade, and C.G. "Wright, Particulate dermal matrix as an injectable soft tissue replacement material," Journal of Biomedical Materials Research, vol. 58, no.1, 2001, pp. 10-15.
連結：
4. Bergeret-Galley, C., "Comparison of resorbable soft tissue fillers," Aesthetic Surgery Journal, vol. 24, no. 1, 2004 ,pp. 33-46.
連結：
6. Hyon, S.-H., et al., "Poly (vinyl alcohol) hydrogels as soft contact lens material," Journal of Biomaterials Science, vol. 5, no. 5, 1994, pp. 397-406.
連結：

Times Cited (1) 〈TOP〉

吳書璇(2014)。製備多孔性聚乳酸微粒於軟組織填補劑之開發。臺北科技大學生物科技研究所學位論文。2014。1-57。

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