十字花科蔬菜吲哚衍生物3,3'-Diindolylmethane對於3T3-L1前脂肪細胞分化的影響

唐筱涵

doi:10.6831/TMU.2015.00019

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十字花科蔬菜吲哚衍生物3,3'-Diindolylmethane對於3T3-L1前脂肪細胞分化的影響

Effects of 3,3'-Diindolylmethane, a cruciferous vegetable indole derivative, on differentiation of 3T3-L1 preadipocytes

唐筱涵 , Masters　　Advisor：陳玉華　　

繁體中文 DOI： 10.6831/TMU.2015.00019

十字花科蔬菜； I3C ； DIM ；脂質生合成作用； Cruciferous vegetable ； I3C ； DIM ； Adipogenesis ； Arnt

Abstract │ Reference (103) │ Altmetrics

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3,3‘-Diindolylmethane (DIM) is an acidic derivative from indole-3-carbinol (I3C), an indole derivative from cruciferous vegetable possessed anti-obesity activities. In vivo biological activities of I3C was thought to be associated with DIM, but the information of DIM on adipogenesis is limited. I3C and DIM are the ligands of the aryl hydrocarbon receptor (AhR) which forms a heterodimer with aryl hydrocarbon receptor nuclear translocator (Arnt). The heterodimer regulates the expressions of hypoxia and xenobiotic metabolism related genes. Both the Arnt and the AhR regulate obesity and its associated processes, but have opposite effects. This study then examined the effects of DIM on adipogenesis and the expressions of related genes and proteins by using 3T3-L1 preadipocytes. The cells were treated with different concentrations of DIM in the presence of differentiation reagents, adipogenesis was then determined. The results showed that DIM increased triglyceride content of differentiated adipocytes, and such effect was accompanied with the increased expressions of related mRNAs and proteins.

Reference ( 103 ) 〈TOP〉

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連結：
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連結：
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