茶子萃取物對高脂飲食大鼠體脂肪蓄積之影響

茶子萃取物 (Camellia sinensis) 富含多酚類、皂苷類，以可促進體內脂肪酸氧化，減少消化道的吸收作用而受到注目。本實驗以雄性 Wistar 大鼠，經一週適應期後分成控制組 (C組)、高脂飲食 (F組)、及高脂飲食補充不同劑量茶子萃取物的兩組 (L組, H組)，每組各10隻。每週測量其體重變化及攝食狀況，經八週的飲食介入後予以犧牲。本研究結果發現：茶子萃取物介入可顯著降低高脂飲食造成腹部脂肪、相對脂肪重及體重增加的情形 (p < 0.05)，同時可以顯著降低高脂飲食造成血漿游離脂肪酸濃度增加的情形 (p < 0.05)。由脂肪細胞激素的分析結果：給予茶子萃取物的攝取後，相較於高脂飲食組，可降低血漿Leptin濃度 (p < 0.05)。綜合以上結果得知：高脂飲食動物模式中，給予茶子萃取物介入，可能經由改善血漿游離脂肪酸濃度、調節體內脂肪細胞激素Leptin的表現，減少副睪、後背脂肪和相對總脂肪的堆積情況，達到減輕高脂飲食所誘發的肥胖及體脂肪蓄積的目的。

關鍵字

高脂飲食；體脂肪蓄積；茶子萃取物；脂肪細胞激素

並列摘要

Tea fruit extract (Camellia sinensis) enriched polyphenols and saponins, has been known to increase ??-oxidation and affect gastrointestinal digestion. In this study, 40 Wistar rats were divided into the control group (AIN-93M diet, high fat diet (modified from AIN-93M containing 57.7% calories from oil), L group (high fat diet with 10.3 g/kg tea fruit extract) and H group (high fat diet with 20.6 g/kg tea fruit extract). The rats were weighted weekly and sacrificed after 8 weeks of experiment. Results showed that diets containing tea fruit extract could significantly reducing in body weight, adipose tissue weight (p < 0.05). Supplement with tea fruit extract led to significantly decrease plasma free fatty acids concentrations (p < 0.05). Besides, there were significantly decrease plasma leptin levels (p < 0.05). Therefore, we concluded that tea fruit extract can improve adipokines expression and prevent fat accumulation of adipose tissue.

並列關鍵字

high fat diet ； tea fruit extract (Camellia sinensis) ； fat accumulation ； adipokines

參考文獻

Ahima RS, Flier JS (2000). Leptin. Annu Rev Physiol 62: 413-437.

Anubhuti, Arora S (2008). Leptin and its metabolic interactions: an update. Diabetes Obes Metab 10: 973-993.

Ashakumary L, Rouyer I, Takahashi Y, Ide T, Fukuda N, Aoyama T et al (1999). Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat. Metabolism 48: 1303-1313.

Belza A, Frandsen E, Kondrup J (2007). Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects. Int J Obes (Lond) 31: 121-130.

Bose M, Lambert JD, Ju J, Reuhl KR, Shapses SA, Yang CS (2008). The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice. J Nutr 138: 1677-1683.

國際替代計量

茶子萃取物對高脂飲食大鼠體脂肪蓄積之影響

全文下載

主題瀏覽