山苦瓜之生理活性探討－抗氧化、抗菌、細胞毒性與抑制Semicarbazide-Sensitive Amine Oxidase活性

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山苦瓜之生理活性探討－抗氧化、抗菌、細胞毒性與抑制Semicarbazide-Sensitive Amine Oxidase活性

Study on The Biological Activities of Different Species from Momordica charantia L. var. abbreviata Seringe: Antioxidation, Antibacteria, Cytotoxicity and Inhibition of Semicarbazide-Sensitive Amine Oxidase Activity

呂岳霖 , Masters　　Advisor：侯文琪　　

繁體中文

苦瓜；抗氧化；抗菌；細胞毒性； Momordica charantia L. var. abbreviata Seringe ； Antioxidant ； Antibacteria ； SSAO

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The water or methanol extracts from sixteen species of Momordica charantia L. var. abbreviata Seringe (MCs) were used for anti-oxidation, cytotoxicity, anti-bacteria and SSAO inhibition screening assays. It was found that the variations among the species of each biological activity were found. For screening of the anti-oxidation activity, the IC50 for the most potent species on DPPH scavenging activity assay was 181 ?g/mL equivalent to 25.500 ?g of Trolox? per gram water extracts. For screening of superoxide radical scavenging activity using autoxidation of pyrogallol assay system, it was found that less number of the water extracts and almost all the methanol extracts exhibited the scavenging activity against superoxide radicals. In the anti-LDL oxidation assay, determined by both the electrophoretic mobility and TBARS assays both extracts of MCs showed positively inhibitory activity on Cu2+-induced LDL peroxidation. Furthermore, the both extracts of MCs showed good scavenging activity on the hydroxyl radical generated by Fenton reaction using the ESR spectrometric method. On the screening of anti-cancer activity, some water and methanol extracts exhibited cytotoxicity on HT 1080 cells. For the D species of MCs, the IC50 of the water and methanol crude extracts were 0.368 and 0.550 mg/mL, respectively, and the cytotoxic activity increased after Sephadex LH-20 purifications. However, the potent extracts with cytotoxicity on HT 1080 cells were also found to have cytotoxic activity on HDF (primary culture cells). Further investigations will be done in the future. On the screening of anti-bacteria activity, all extracts had no activities against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa, however, some extracts did have the inhibitory activity on the growth of Escherichia coli and Salmonella enterica. The inhibitory activity remained even after heating at 100°C for 5 minutes. On the screening of SSAO inhibitory activity, the methanol extracts of MCs showed potent inhibitory activity against SSAO; while only two species of MCs’ water extracts reached the 50% inhibition. The species of the methanol extracts reached the 90% inhibition including D, E, F, H, K, N and P, which the IC50 were 0.594, 0.653, 0.637, 0.673, 0.397, 0.386 and 0.750 mg/mL, respectively.

Reference ( 165 ) 〈TOP〉

何曼德、McDonald, L. C.，楊采菱。2000。1998年臺灣地區之抗生素抗藥性監測。院內感染控制雜誌 10, 278-292
連結：
Ahmed, I., Lakhani, M.S., Gillett, M., John, A., Raza, H., 2001. Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats. Diabetes Res Clin Pract 51, 155-161
連結：
Akihisa, T., Kimura, Y., Kasahara, Y., Kumaki, K., Thakur, S., Tamura, T., 1997. 7-oxodihydrokarounidiol-3-benzoate and other triterpenes from the seeds of Cucurbitaceae. Phytochemistry (Oxford) 46(7), 1261-1266
連結：
Ali, L., Khan, A.K., Mamun, M.I., Mosihuzzaman, M., Nahar, N., Nur-e-Alam, M., Rokeya, B., 1993. Studies on hypoglycemic effects of fruit pulp, seed, and whole plant of Momordica charantia on normal and diabetic model rats. Planta Med 59, 408-412
連結：
Ames, B.N., 1983. Dietary carcinogens and anticarcinogens: Oxygen radicals and degenerative disease. Science 221, 1256-1264
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