革新的疾病相關路徑鑑定法：以心肌梗塞跨平台資料為例

吳東懋

doi:10.6831/TMU.2012.00223

18.208.126.232，Hello！

Close
Search Quick Search Advanced Search Publication Search	Personal Service Member Login Searching History Use Bonus Card SYMSKAN
Browse Browse by University of Graduate Thesis Browse by Pinyin of Graduate Thesis Browse by Conference Proceedings Topic Browse by Conference Proceedings Publisher Browse by Pinyin of Conference Proceedings Browse by eBook Category Browse by eBook Topic Browse by eBook Publisher
Customer Services Authorize Airiti Recommend a Journal

Search Symbol (Half-width)	Description of Search Symbols
Space	"AND" indicates the intertwining of key terms used in a search
Double Quotation Marks ("") ( " " )	Double quotation marks indicate the beginning and end of a phrase, and the search will only include terms that appear in the same order of those within the quotations. Example: "image process" ： " image process "
?	Indicates a variable letter. Entering two ? will indicate two variable letters, and so on. Example: "Appl?", search results will yield apple, apply… e , appl y … ( (often used to English word searches) )
*	Indicates an unlimited number of variable letters to follow, from 1~n. Example: Enter "appl*", search results will yield apple, apples, apply, applied, application…(often used in English word searches) e , appl es , appl y , appl ied , appl ication … ( (often used to English word searches) )
AND、OR、NOT	Boolean logic combinations of key words is a skill used to expand or refine search parameters. (1) AND (1) AND: Refines search parameters (2) OR (2) OR: Expands search parameters (3) NOT: Excludes irrelevant parameters

DOI stands for Digital Object Identifier （ D igital O bject I dentifier ） ,
and is the unique identifier for objects on the internet. It can be used to create persistent link and to cite articles.

Using DOI as a persistent link

To create a persistent link, add「http://dx.doi.org/」「 http://dx.doi.org/ 」 before a DOI.
For instance, if the DOI of an article is 10.5297/ser.1201.002 , you can link persistently to the article by entering the following link in your browser: http://dx.doi.org/ 10.5297/ser.1201.002 。
The DOI link will always direct you to the most updated article page no matter how the publisher changes the document's position, avoiding errors when engaging in important research.

Cite a document with DOI

When citing references, you should also cite the DOI if the article has one. If your citation guideline does not include DOIs, you may cite the DOI link.

DOIs allow accurate citations, improve academic contents connections, and allow users to gain better experience across different platforms. Currently, there are more than 70 million DOIs registered for academic contents. If you want to understand more about DOI, please visit airiti DOI Registration （ doi.airiti.com ）。

Data Source

Basic & Applied Sciences > Information Science
Health & Medical Care > Medical Sciences
College of Medical Science and Technology > Graduate Institute of Biomedical Informatics

Bibliography Management Tool

Related Links

Report an Issue

Purchase Single Articles

Download PDF

革新的疾病相關路徑鑑定法：以心肌梗塞跨平台資料為例

A Revolutionary Method for Disease Pathways Identification Using Myocardial Infarction Cross-Platform Data

吳東懋 , Masters　　Advisor：李元綺　　

繁體中文 DOI： 10.6831/TMU.2012.00223

基因調控網路；路徑分析； Gene Network ； Pathway Analysis

Abstract │ Reference (30) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

Since the day we were born, we have been afflicted with all kinds of illness and diseases. To reduce the pain and fear, all kinds of approaches to attack diseases have been developed. From the aspect of genetics studies, the researchers used to work on a couple of genes that might relate to diseases in all their scientific life. However, along with the advance of biotechnology, we are able to trace and monitor the alteration of gene expression in a whole-genome scale. Furthermore, the chances are the approaches have been moved from individual gene studies to gene-gene interactions and even the gene network, as it is believed that genes are collaboratively functioning in groups instead of working by themselves alone. Therefore, pathway analysis has been getting more attention recently. However, the pathway analysis used update exists many unsolved issues, most importantly, it lacks the integrity of whole-genome regulated networks that actually reflect the gene reaction pathways. We develop a method to identify “Disease-associated Pathways”. Here in this study, we will (1) develop a regulatory gene network by combining each gene-gene reaction pair, (2) identify the shortest pathways from a whole genome network, (3) establish pathway analysis algorithms to calculate the full pathway expression value, and (4) distinguish the disease and non-disease pathways by incorporating microarray data. The purpose of this pipe-line approach is to quest for disease-associated pathways and by unveiling the pathways, it will also provide a better choice for drug target in pharmaceutical industry in the near future.

Reference ( 30 ) 〈TOP〉

1.(2006) The Gene Ontology (GO) project in 2006. Nucleic Acids Res 34: D322-326
連結：
2.(2008) The Gene Ontology project in 2008. Nucleic Acids Res 36: D440-444
連結：
3.Alvo M, Liu Z, Williams A, Yauk C (2010) Testing for mean and correlation changes in microarray experiments: an application for pathway analysis. BMC Bioinformatics 11: 60
連結：
4.Chen L, Xuan J, Gu J, Wang Y, Zhang Z, Wang TL, Shih leM (2012) Integrative network analysis to identify aberrant pathway networks in ovarian cancer. Pac Symp Biocomput 2012:31-42
連結：
5.Fang Z, Tian W, Ji H, (2011) A network-based gene-weighting approach for pathway analysis. Cell Res. 2011 Sep 6. doi:10.1038/cr.2011.149.
連結：

Altmetrics

〈TOP〉

E-mail ：

When an article is available to download, a notice will be sent to your mailbox address.

E-mail ：