大葉瓜馥木化學成分及其生物活性之研究

林佳貞

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大葉瓜馥木化學成分及其生物活性之研究

Chemical Constituents and Biological Investigations of Fissistigma latifolium

林佳貞 , Masters　　Advisor：藍于琁　　

繁體中文

大葉瓜馥木；化學成分；生物活性； Biological ； Chemical Constituents ； Fissistigma latifolium

Abstract │ Reference (64) │ Altmetrics

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Fissistigma latifolium (Annonaceae) is a climbing shrub found in low altitude forest and mainly distributed in tropical Asia. Previous studies showed that the Fissistigma genera has numerous classes of alkaloids and pharmacological activity， such as analgesic, anti-inflammatory, antimicrobial, anti-tumor and cardiovascular effects. In this study, active compounds were isolated and purified from F. latifolium in order to develop new medicine resources.
    There were fifteen compounds isolated from  F. latifolium crude extracts, and their structures were established by NMR spectroscopy and references comparison. These compounds includ seven alkaloids, oxocrebanine (1), lysicamine (2), liriodenine (3), atherospermidine (4), aristolactam AIIIa (5), goniothalactam (6), piperlactam A (7); five flavonoids, 5,6,7-trimethoxyflavone (8), 2,5,6,7-tetramethoxyﬂavan (9)、2-hydroxy-4,5,6-trimethoxydihydrochalcone (10), 4,6-dimethoxy-2,5-quinodihydrochalcone (11), [3-3′]bi-2-hydroxy-4,5,6- trimethoxydihydrochalcone (12); one benzyl, 2′-hydroxy-4′,5′,6′- trimethoxybenzil (13) and two benzenoid, vanillic acid (14) and benzaldehyde (15). Compounds 9, 11, 12 and 13, were isolated from natural sources for the first time. Compounds 8, 10 and 15, were isolated for the first time from the Fissistigma species.
All compounds were evaluated for their anti-inflammatory activities and anti-tumor activity. Compound 9 showed significant anti-inflammatory activity and inhibited the superoxide anion generation in human neutrophils by induced fMLP/CB. Compound 11 showed cytotoxicity against the human breast cancer cell lines MDA-MB-231.

Reference ( 64 ) 〈TOP〉

2. 賈宜琛，毛瓜馥木與多脈瓜馥化學成分及異奎寧型生物鹼抗血小板凝集作用之研究，高雄醫學大學藥學研究所博士論文，2000.
連結：
4. Chen, Qi.; Lin, B. L.; Chen, Z. X.; Wang, R. J.; Bi, M.; Tao, Z. P.; Xiong, S. P.; Wang, J. H., “Effect of total alkaloids of Fissistigma oldmamii on cAMP and isolated hearts” Yaoxue Xuebao 1985, 6, 48-51.
連結：
5. Wu, Y. C.; Lu, S. T.; Wu, T. S.; Lee, K. H., “Kuafumine, a novel cytotoxic oxoporphine alkaloid from Fissistigma glaucescens” Heterocycles 1987, 26, 9-12.
連結：
6. Yatmah, A.; Khalijah A.; A. Hamid, A., “An antimitotic and cytotoxic chalcone from Fissistigma lanuginosum” J. Nat. Prod. 1995, 58, 1160-1166.
連結：
8. Lu, S. T.; Wu, Y. C.; Leou, S. P., “Alkaloids of Formosan Fissistigma and Goniothalamus species.” Phytochemistry 1985, 24, 1829-1834.
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