大葉瓜馥木化學成分及其生物活性之研究

林佳貞

54.85.57.0，Hello！

Close
Search Quick Search Advanced Search Publication Search	Personal Service Member Login Searching History Use Bonus Card SYMSKAN
Browse Browse by University of Graduate Thesis Browse by Pinyin of Graduate Thesis Browse by Conference Proceedings Topic Browse by Conference Proceedings Publisher Browse by Pinyin of Conference Proceedings Browse by eBook Category Browse by eBook Topic Browse by eBook Publisher
Customer Services Authorize Airiti Recommend a Journal

Search Symbol (Half-width)	Description of Search Symbols
Space	"AND" indicates the intertwining of key terms used in a search
Double Quotation Marks ("") ( " " )	Double quotation marks indicate the beginning and end of a phrase, and the search will only include terms that appear in the same order of those within the quotations. Example: "image process" ： " image process "
?	Indicates a variable letter. Entering two ? will indicate two variable letters, and so on. Example: "Appl?", search results will yield apple, apply… e , appl y … ( (often used to English word searches) )
*	Indicates an unlimited number of variable letters to follow, from 1~n. Example: Enter "appl*", search results will yield apple, apples, apply, applied, application…(often used in English word searches) e , appl es , appl y , appl ied , appl ication … ( (often used to English word searches) )
AND、OR、NOT	Boolean logic combinations of key words is a skill used to expand or refine search parameters. (1) AND (1) AND: Refines search parameters (2) OR (2) OR: Expands search parameters (3) NOT: Excludes irrelevant parameters

DOI stands for Digital Object Identifier （ D igital O bject I dentifier ） ,
and is the unique identifier for objects on the internet. It can be used to create persistent link and to cite articles.

Using DOI as a persistent link

To create a persistent link, add「http://dx.doi.org/」「 http://dx.doi.org/ 」 before a DOI.
For instance, if the DOI of an article is 10.5297/ser.1201.002 , you can link persistently to the article by entering the following link in your browser: http://dx.doi.org/ 10.5297/ser.1201.002 。
The DOI link will always direct you to the most updated article page no matter how the publisher changes the document's position, avoiding errors when engaging in important research.

Cite a document with DOI

When citing references, you should also cite the DOI if the article has one. If your citation guideline does not include DOIs, you may cite the DOI link.

DOIs allow accurate citations, improve academic contents connections, and allow users to gain better experience across different platforms. Currently, there are more than 70 million DOIs registered for academic contents. If you want to understand more about DOI, please visit airiti DOI Registration （ doi.airiti.com ）。

Data Source

Health & Medical Care > Pharmacology
College of Pharmacy > Master's Program, School of Pharmacy

Bibliography Management Tool

Related Links

Report an Issue

Search in Library

There is no full-text available at the moment. Airiti would like to request author's authorization. I would like to provide authorization.

大葉瓜馥木化學成分及其生物活性之研究

Chemical Constituents and Biological Investigations of Fissistigma latifolium

林佳貞 , Masters　　Advisor：藍于琁　　

繁體中文

大葉瓜馥木；化學成分；生物活性； Biological ； Chemical Constituents ； Fissistigma latifolium

Abstract │ Reference (64) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

Fissistigma latifolium (Annonaceae) is a climbing shrub found in low altitude forest and mainly distributed in tropical Asia. Previous studies showed that the Fissistigma genera has numerous classes of alkaloids and pharmacological activity， such as analgesic, anti-inflammatory, antimicrobial, anti-tumor and cardiovascular effects. In this study, active compounds were isolated and purified from F. latifolium in order to develop new medicine resources.
    There were fifteen compounds isolated from  F. latifolium crude extracts, and their structures were established by NMR spectroscopy and references comparison. These compounds includ seven alkaloids, oxocrebanine (1), lysicamine (2), liriodenine (3), atherospermidine (4), aristolactam AIIIa (5), goniothalactam (6), piperlactam A (7); five flavonoids, 5,6,7-trimethoxyflavone (8), 2,5,6,7-tetramethoxyﬂavan (9)、2-hydroxy-4,5,6-trimethoxydihydrochalcone (10), 4,6-dimethoxy-2,5-quinodihydrochalcone (11), [3-3′]bi-2-hydroxy-4,5,6- trimethoxydihydrochalcone (12); one benzyl, 2′-hydroxy-4′,5′,6′- trimethoxybenzil (13) and two benzenoid, vanillic acid (14) and benzaldehyde (15). Compounds 9, 11, 12 and 13, were isolated from natural sources for the first time. Compounds 8, 10 and 15, were isolated for the first time from the Fissistigma species.
All compounds were evaluated for their anti-inflammatory activities and anti-tumor activity. Compound 9 showed significant anti-inflammatory activity and inhibited the superoxide anion generation in human neutrophils by induced fMLP/CB. Compound 11 showed cytotoxicity against the human breast cancer cell lines MDA-MB-231.

Reference ( 64 ) 〈TOP〉

2. 賈宜琛，毛瓜馥木與多脈瓜馥化學成分及異奎寧型生物鹼抗血小板凝集作用之研究，高雄醫學大學藥學研究所博士論文，2000.
連結：
4. Chen, Qi.; Lin, B. L.; Chen, Z. X.; Wang, R. J.; Bi, M.; Tao, Z. P.; Xiong, S. P.; Wang, J. H., “Effect of total alkaloids of Fissistigma oldmamii on cAMP and isolated hearts” Yaoxue Xuebao 1985, 6, 48-51.
連結：
5. Wu, Y. C.; Lu, S. T.; Wu, T. S.; Lee, K. H., “Kuafumine, a novel cytotoxic oxoporphine alkaloid from Fissistigma glaucescens” Heterocycles 1987, 26, 9-12.
連結：
6. Yatmah, A.; Khalijah A.; A. Hamid, A., “An antimitotic and cytotoxic chalcone from Fissistigma lanuginosum” J. Nat. Prod. 1995, 58, 1160-1166.
連結：
8. Lu, S. T.; Wu, Y. C.; Leou, S. P., “Alkaloids of Formosan Fissistigma and Goniothalamus species.” Phytochemistry 1985, 24, 1829-1834.
連結：

Altmetrics

〈TOP〉

E-mail ：

When an article is available to download, a notice will be sent to your mailbox address.

E-mail ：