0.7)。體外實驗結果顯示瑪黛茶萃出物會抑制大鼠CYP3A (IC50 = 132.2 μg/mL)與人類CYP3A4 (IC50 = 210.0 μg/mL)之活性,進一步實驗判定為競爭型抑制作用。實驗二以雄性SD大鼠評估瑪黛茶對APAP代謝之影響,大鼠分別食用含有1.5%與3%瑪黛茶葉粉末(Mate tea leaves, MTL)之飼料兩週,隔夜禁食後腹腔注射APAP (1000 mg/kg b.w.),部分大鼠放入代謝籠中收取尿液,12小時後犧牲,取其血漿和肝臟測定肝腎功能指標與APAP及其代謝物濃度與藥物代謝酵素活性;結果發現APAP明顯提高肝損傷指標aspartate transaminase (AST)和lactate dehydrogenase (LDH),而食用3%瑪黛茶葉粉末之大鼠再給予注射APAP後會更明顯增加APAP的肝損傷。此外,攝食含瑪黛茶葉粉末之大鼠血漿、肝臟及尿液中APAP-GSH濃度皆會明顯增加,肝臟中CYP3A和CYP1A2活性亦有顯著上升。值的注意的是,攝食瑪黛茶葉粉末飲食會提高肝臟中APAP protein adduct含量。由以上結果顯示瑪黛茶具有抗氧化活性,但卻會增加大鼠肝臟中APAP經由CYP代謝而對肝臟造成損傷。' > Airiti Library
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  1. 陳香郿 (2007). 人類有基因離子運輸器OATP1B1基因型與抗結核藥物治療期間肝損傷之關聯研究. 台北醫學大學藥學系碩士論文.
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  2. 傅嘉宏 (2004). 溫感性生物可分解之高分子聚合物於藥物傳釋及輸送之研究. 國立成功大學臨床藥學研究所碩士論文.
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  3. 游士儒 (2010). Acetaminophen 藥物過量之治療. 耕莘藥訊 49: 1-7.
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  4. 賴國誌, 廖永智, 林美智, 顧祐瑞, 徐雅慧, 蔡麗瑤, 李蕙君, 呂康祖, 劉宜祝, and 羅吉方 (2011). 九十九年調製劑中藥檢出西藥成分之分析. 食品藥物研究年報 2: 339-349.
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  5. 賴國誌, 廖永智, 林美智, 顧祐瑞, 蔡麗瑤, 李蕙君, 范振一, 王依婷, 劉宜祝, 林哲輝, and 羅吉方 (2010). 九十八年度調製劑中藥檢出西藥情形之分析. 食品藥物研究年報 1: 212-223.
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