D-半乳糖誘發小鼠老化之免疫反應研究

廖建忠

doi:10.6833/CJCU.2012.00147

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D-半乳糖誘發小鼠老化之免疫反應研究

The study of immune responses on D-galactose induced aging mice

廖建忠 , Masters　　Advisor：陳妙齡　　

繁體中文 DOI： 10.6833/CJCU.2012.00147

D-半乳糖；老化；免疫； D-galactose ； aging ； immune

Abstract │ Reference (119) │ Times Cited (2) │ Altmetrics

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Age-related changes of the immune system contribute to the increased susceptibility of elderly persons to infectious diseases. Mice chronically injected with D-galactose (D-gal) have been used as an animal aging model. However, less attention has been paid to the changes of immune responses on D-gal induced aging mice. To investigate the changes of immune responses on D-gal injected aging mice, the BALB/c and C57BL/6j were used in this study.
    First, BALB/c mice of model control (MC), Gal-100 and Gal-150 groups were subcutaneous injected with 0, 100 and 150 mg/Kg/day for 8 weeks, individually, and compared with nature aging mice (NA) in this study. The brain and supernatants form immune cell culture were collected for cytokines assay. The Aβ42 in brain homogenates and serum IL-6 levels from the BALB/c mice injected with 150 mg/Kg/day D-gal significantly higher than MC group, as well as IL-6 production from peritoneal macrophages and IL-4 secretion from splenocytes. The indicators of oxidation and antioxidant, kidney TBARS content increased, brain and liver GSH content increased, and the liver SOD activity increased.
    The C57BL/6J mice of model control (MC), Gal-100,Gal-150 and Gal-500 groups were subcutaneous injected with 0, 100 , 150 and 500 mg/Kg/day for 8 weeks. The brain and supernatants form immune cell culture were collected for cytokines assay. The results indicated that Aβ42 were significantly increased in brain from Gal-500 group, opposite to the activity of the mice. Furthermore, 150 mg/Kg/day D-galinjected mice had higher cytokines production, especially TNF-α level in brain homogenates, but not in Gal-500 group. Moreover, D-gal injection decreased the IL-2 secretion, and increased the IL-4 production by splenocytes, but not reach significantly effects. 500 mg/Kg/day D-gal injection reduced CD4 and MHC-II expression in splenocytes, as well as actived macrophages.
    To summary the results of this study, BALB/c mice injected with 150 mg/Kg D-gal could induce Aβ and pro-inflammatory cytokines production. C57BL/6j mice injected with 500 mg/Kg D-gal could induce aging responses and pro-inflammatory cytokines production, but decrease antigen presenting cell and T cell population. This study demonstrated that mice injected with D-gal can be use as the immune-regulatory study of aging.

Reference ( 119 ) 〈TOP〉

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