Aquaporin 4及MAOA基因對使用Olanzapine, Risperidone及Paliperidone的精神分裂症患者的影響

鍾廷聖

doi:10.6833/CJCU.2012.00220

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Aquaporin 4及MAOA基因對使用Olanzapine, Risperidone及Paliperidone的精神分裂症患者的影響

Different Impacts of Aquaporin 4 and MAOA Allele Variation Among Olanzapine, Risperidone, and Paliperidone in Schizophrenia

鍾廷聖 , Masters　　Advisor：紀宗呈　　

繁體中文 DOI： 10.6833/CJCU.2012.00220

精神分裂症； Apoptosis ； Aquaporin 4 ； Monoamine oxidase A

Abstract │ Reference (60) │ Times Cited (1) │ Altmetrics

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Background: Apoptosis has been considered to be involved in schizophrenia. Water channels are modulated just prior to apoptosis. In the aquaporin family, aquaporin 4 (AQP4) is most highly expressed in the brain, and is supposed to play an important role in a neuronal environment. In this clinical study, we investigated the relationship between the AQP4 polymorphism and drug response in schizophrenia under the control of the MAOA (Monoamine oxidase A) promoter gene. 
Methods: We recruited 91 patients with schizophrenia, and they were randomized to received olanzapine (numbers: 44), risperidone (numbers: 23), or paliperidone (numbers: 24). Genotyping of AQP4 and MAOA polymorphisms was done in all patients. 
Results: Patients with the AQP4 non-C polymorphism needed a higher dosage of olanzapine for treatment (z= 4.163, P = 0.041), and patients with a short form of the MAOA polymorphism needed a higher dosage of risperidone for treatment (z= 5.124, P = 0.024). Patients who smoked cigarettes needed a higher dosage of olanzapine for treatment (z= 4.905, P = 0.027), but cigarette smoking did not affect the dosage of paliperidone. 
Conclusions: The AQP4 polymorphism may have an effect in influencing the dosage of olanzapine. However, the role of AQP4 polymorphisms in blood-brain barrier and different neuroprotective effects need further exploration in future study.

Reference ( 60 ) 〈TOP〉

Amiry-Moghaddam, M. and O. P. Ottersen (2003). "The molecular basis of water transport in the brain." Nat Rev Neurosci 4(12): 991-1001.
連結：
Andreasen, N., H. A. Nasrallah, et al. (1986). "Structural abnormalities in the frontal system in schizophrenia. A magnetic resonance imaging study." Arch Gen Psychiatry 43(2): 136-144.
連結：
Badaut, J., F. Lasbennes, et al. (2002). "Aquaporins in brain: distribution, physiology, and pathophysiology." J Cereb Blood Flow Metab 22(4): 367-378.
連結：
Bai, O., H. Zhang, et al. (2004). "Antipsychotic drugs clozapine and olanzapine upregulate bcl-2 mRNA and protein in rat frontal cortex and hippocampus." Brain Res 1010(1-2): 81-86.
連結：
Blackwell, B. (1979). "Treatment adherence: a contemporary overview." Psychosomatics 20(1): 27-35.
連結：

Times Cited (1) 〈TOP〉

李翔群(2007)。運動明星的形成與反思。臺灣師範大學運動與休閒管理研究所學位論文。2007。1-171。

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