電活性氧化鐵/嵌段共聚物複合材料於磁性熱療之應用

近十年癌症已成為全球死因之首，對於癌症治療，學術界與醫療界皆積極地發展新的治療技術，期望能減少病患在治療時的痛苦與副作用的產生。截至目前，磁性熱療法已被視為最有潛力的癌症治療方法，但當磁性粒子植入於人體而沒有固定在癌細胞區域時，可能會隨著血液流動而遷移至其他健康細胞使組織發炎，另外當磁性粒子在血管裡流動的過程中，也可能會造成血管栓塞，而導致心血管疾病的產生。因此本研究發展表面修飾之Fe3O4奈米粒子，將其混摻進嵌段共聚物中，並利用電活性寡聚物苯胺四聚體 (tetraaniline)，製備成電活性氧化鐵/嵌段共聚物複合材料，使其克服無法固定於癌細胞區域之缺點，並藉由控制Fe3O4奈米粒子與苯胺四聚體的含量，來達到最佳的熱療效果。磁性氧化鐵 (Fe3O4) 粒子於水熱法200 ̊C合成，使用油胺 (oleylamine，C18H37N) 作為界面活性劑客製化Fe3O4奈米粒子的大小，並系統性研究其成長，可使粒徑調控於15.2 nm到9.2 nm之間，此超順磁Fe3O4奈米粒子的飽和磁化強度為71.2 emu/g。並將水熱法合成之12.2nm Fe3O4奈米粒子、苯胺四聚體，置入磺酸化三嵌段共聚高分子 (sulfonated polystyrene-block-poly (ethylene-ran-butylene) -block- polystyrene，S-SEBS) 中，製備成電活性氧化鐵/嵌段共聚物複合材料，並改變Fe3O4奈米粒子與苯胺四聚體含量，在高頻率交流磁場測試下，探討Fe3O4奈米粒子與苯胺四聚體，對加熱效果之影響。實驗結果證實：當S-SEBS高分子膜內的Fe3O4奈米粒子愈多時，加熱效果愈好；苯胺四聚體雖具有導電的功能，但其導電能力仍太低，使得渦流損耗無法明顯表現出來，故溫度提升的來源主要還是來自Fe3O4奈米粒子的Neel 磁鬆弛損耗與Brownian摩擦損耗。

關鍵字

磁性熱療法； Fe3O4粒子；苯胺四聚體；嵌段共聚高分子

並列摘要

Cancer has been one of the leading causes of human death for centuries. There are close to 10 million deaths worldwide every year due to the cancer-related diseases. Considerable effort has been devoted to developing new treatments to reduce and control cancers. Magnetic hyperthermia is the promising strategy to treat cancers due to its effectiveness with only mild side effects. However, the disadvantage of the magnetic hyperthermia is that the magnetic particles are not fixed in the area of cancer cells so that they can migrate to normal cells, which thus causing tissue inflammation, or cardiovascular disease. The goal of this study is to develop electroactive iron oxide / block copolymer composites, which surface-modified iron oxide particles and electroactive tetraaniline were immobilized in block copolymer to prevent them from migration. The optimal performance of magnetic hyperthermia was obtained by controlling the added amount of the iron oxide particles and tetraaniline. Magnetic iron oxide (Fe3O4) particles were synthesized using hydrothermal method at 200 ̊C. In addition, oleylamine surfactant (C18H37N) was utilized to control the Fe3O4 particle size ranging from 15.2 nm to 9.2 nm. The obtained Fe3O4 particles are superparamagnetic with saturation magnetization close to 71 emu / g. Various amounts of Fe3O4 particles and tetraaniline were incorporated in (sulfonated polystyrene-block-poly (ethylene-ran-butylene)-block- polystyrene，S-SEBS) block copolymer to develop electroactive iron oxide / block copolymer composites and their hyperthermia performance was evaluated at high frequency alternating magnetic field. The experimental results show that the heating rate increased as increasing the incorporated amount of Fe3O4 nanoparticles in the composites. Although tetraaniline has a conductive feature, its conductivity is still not enough so that its eddy current loss cannot significantly contribute to hyperthermia effect. Hence, the main sources for increasing temperature are Neel relaxation loss and Brownian friction loss from Fe3O4 magnetic particles.

並列關鍵字

Magnetic hyperthermia therapy ； Fe3O4 nanoparticles ； tetraaniline ； triblock copolymer

參考文獻

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電活性氧化鐵/嵌段共聚物複合材料於磁性熱療之應用

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