Part 1：α-羥基乙酸衍生物的合成研究
Part 2：6-乙氧羰基- 5H-薁併[1,8a,8-c,d]噠秦衍生物合成研究

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Part 1：α-羥基乙酸衍生物的合成研究 Part 2：6-乙氧羰基- 5H-薁併[1,8a,8-c,d]噠秦衍生物合成研究

Part 1：The synthesis of α-hydroxyl acetic acid derivatives Part 2：The synthesis of 6-ethoxycarbonyl-5H-azuleno [1,8a,8-c,d] pyridazine derivatives

吳姝嫻 , Masters　　Advisor：吳吉輝　　

繁體中文

8-c ； α-羥基乙酸衍生物； d]噠秦衍生物合成研究； 8a ； 6-乙氧羰基- 5H-薁併[1 ； 6-ethoxycarbonyl-5H-azuleno [1 ； d] ； 8-c ； α-hydroxyl acetic acid derivatives ； 8a

Abstract │ Reference (12) │ Times Cited (1) │ Altmetrics

Abstract 〈TOP〉

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Abstract

This thesis includes two parts. 
    The first part discusses the synthesis of α-hydroxyl acetic acid derivatives: The reaction of methyl benzoylformate with isopropylmagnesium chloride at 0℃ afforded a mixture of methyl 2-hydroxy-3-methyl-2-phenylburate and methyl benzoylformate, which can not  be separated chromatographically. The methyl 2-hydroxy-3-methyl-2-phenylburate was finally purified by addition of primary amine to the reaction mixture to remove methyl benzoylformate. The methyl 2-hydroxy-3-methyl -2-phenylburate was then acidified to give  methyl 2-hydroxy-3-methyl-2-phenylburic acid.
The second part discusses the synthesis of 6-ethoxycarbonyl-5H- azuleno[1,8a,8-c,d]pyridazine derivatives: The reactions of ethyl 3-formylazulene-1-carboxylate derivatives with excess hydrazine and phenylhydrazine at 100℃ afforded 6-ethoxycarbonyl-5H-azuleno [1,8a,8-c,d]pyridazine and 6-ethoxycarbonyl-1-phenyl-5H-azuleno [1,8a,8-c,d]pyridazine derivatives, respectively. These new compounds were characterized by IR, NMR, Mass spectra.

Reference ( 12 ) 〈TOP〉

3. J. C. Sowden and R. Schwffer, J. Am. Chem. Soc., 1951, 73, 4662
連結：
4. Kadin and Cannm, J. Org. Chem., 1961, 27, 240
連結：
5. Robert M. Einterz, Jay W. Ponder, and Ronald S. Lenox, J. Chem. Edu., 1977, 54, 382
連結：
1. 翁孟玉碩士論文 , 國立成功大學臨床藥學研究所 , 1997
2. 魏致源碩士論文 , 中正理工學院應用化學研究所 , 1999

Times Cited (1) 〈TOP〉

魏明雄(2002)。含薁核α-羥基酯類之合成研究。中原大學化學研究所學位論文。2002。1-74。

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