研究聚偏二氟乙烯靜電紡絲奈米纖維的表面羧基化於人體血液分離之應用

金奕彤

doi:10.6840/cycu202100437

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研究聚偏二氟乙烯靜電紡絲奈米纖維的表面羧基化於人體血液分離之應用

Surface carboxylation of poly(vinylidene fluoride) electrospun nanofibers for human blood separation

金奕彤 , Masters　　Advisor：費安東　　Co-advisor ：張雍

英文 DOI： 10.6840/cycu202100437

電紡絲薄膜；聚偏二氟乙烯；血液分離； Electrospun membranes ； Poly(vinylidene fluoride) ； Blood separation

Abstract │ Reference (133) │ Altmetrics

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This work reports the association of poly(styrene-co-acrylic acid) random copolymer, P(S-r-AA), with poly(vinylidene fluoride) (PVDF) in the fabrication of electrospun fibers for blood filtration. At first, effort was put into the determination of the styrene/acrylic acid molar ratio in P(S-r-AA) copolymer that would improve best the wetting of nanofibers. With a 50/400 molar ratio, the water contact angle of the modified membrane (M5) was 127 ± 1°, while it was slightly higher for the unmodified membrane (M0, 136 ± 1°). However, the copolymer significantly improved hydration after prolonged contact of the membrane with an aqueous medium, as the swelling ratio increased dramatically from 19 % (M0) to 1600 % (M5). Nanofibers were all found to be physically and chemically homogeneous, with a pore size increasing from 0.56 µm to 1.25 µm for M0 and M5, respectively, and a regular copolymer distribution on the surface. While no flow could be recorded through M0 with white blood cells (WBCs) concentrate, 10-fold diluted whole blood or whole blood, separation was achievable with M5. 100%, 100% and 99.99% retention of leukocytes was measured with WBCs concentrate, 10-fold diluted whole blood, and pure whole blood using this membrane. Besides, it allowed to recover 79% of red blood cells. Although efforts are still needed to further enhance the biocompatibility of nanofibers and the RBCs recovery, the results of this study prove that PVDF-based nanofibers have a great potential as separation media of whole blood.

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References
[1.] Giangrande, P.L., The history of blood transfusion. Br J Haematol, 2000. 110(4): p. 758-67.
[2.] Lozano, M. and J. Cid, Frederic Duran-Jorda: a transfusion medicine pioneer. Transfus Med Rev, 2007. 21(1): p. 75-81.
[3.] Keitel, S., ed. The Guide to the preparation, use and quality assurance of blood components. 19th ed. 2017, the European Directorate for the Quality of Medicines HealthCare of the Council of Europe (EDQM). Europe.
[4.] Eppley, B.L., J.E. Woodell, and J. Higgins, Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg, 2004. 114(6): p. 1502-8.

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