帶電性磁性奈米粒子應用於精子移動控制

王天悅

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帶電性磁性奈米粒子應用於精子移動控制

Sperm Movement Control Utilizing Surface Charged Modified Magnetic Nanoparticles

王天悅 , Masters　　Advisor：章明　　

繁體中文

磁控；帶電性磁性奈米粒子；精子； surfaced charged magnetic nanoparticles ； magnetic control ； sperm

Abstract │ Reference (50) │ Altmetrics

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Oligozoospermia or especially asthenospermia is the significant issue related to males for infertility. A popular method to increase the chance of pregnancy is intracytoplasmic sperm injection (ICSI). However, the process is complicated,  expensive and can not be implemented in vivo. As shown from previous research, the surface membrane of the sperm is negatively charged. The stronger the negative charge may indicate that the sperm has a more complete cell membrane. (M.H Nasr-Esfahani and T. Marziyeh, 2015). The objective of this research is to establish a system to enhance the movement of sperm by using a combination of oscillating and static magnetic field, thus improving the probability of pregnancy. The goal for this research is to augment the velocity of inactive sperm with magnetically controlled nanoparticles within a variying magnetic field.
With very high biocompatibility and super magnetic characteristics, iron oxide(Fe3O4) magnetic nanoparticles(MNPs) are used in this research. Based on Coulomb's law, positively charged MNPs are attracted to the negativly charged cell membrane and attach to help guide it’s movment when placed in a magnetic field. Negatively charged MNPs will repel the sperm cell’s negativly charged surface through the magnetic fluid can therefore be used to direct their movement when introduced to a magnetic field. The permanent magnet in the system is to produce a static magnetic field and gradient and then magnetize the MNPs.
Experimental results show that positively charged MNPs were attracted to the negatively charged cell membrane of sperms and the movement speed of the sperms was about 40μm/s at a magnetic field strength of 1.48T. As negatively charged MNPs weren’t attracted to the sperm cell’s negatively charged surface, the sperms would move by themselves without magnetic control. When sperms move in a ferrofluid, no matter the ferrofluid was modified by positively or negatively charged MNPs, sperms would move with the movement of the magnetic fluid, and the maximum moving speed were about 100μm/s and 80μm/s under the magnetic field strength of 1.48T, respectively. The motion velocity of sperms reveals a linear dependence to the magnetic field strength and the field gradient and quadratic dependence with the distance between permanent magnet and the sperm. Our research has verified that the proposed sperm-magnetic controlling technology with MNPs is possible to improve the activity of sperms.

Reference ( 50 ) 〈TOP〉

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連結：
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連結：
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連結：
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