探討雄性費洛蒙對成年雌鼠副嗅球內之神經元新生的影響

吳俊翰

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探討雄性費洛蒙對成年雌鼠副嗅球內之神經元新生的影響

The effects of male pheromones on adult neurogenesis in the accessory olfactory bulb of female mice

吳俊翰 , Masters　　Advisor：王慈蔚　　

英文

神經元新生；神經幹細胞；費洛蒙；布魯斯效應；正腎上腺素； neurogenesis ； neural stem cell ； pheromone ； Bruce effect ； norepinephrine

Abstract │ Reference (41) │ Altmetrics

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It has been known that stem cells exist in two areas of adult mammalian brains. One of these is the subventricular zone along the lateral ventricle. These stem cells give rise to neuroblasts and differentiate into olfactory bulb interneurons which play important roles in odor discrimination. This process is called neurogenesis and is composed by four aspects: proliferation, migration, differentiation and survival. The olfactory bulb consists of two functionally distinct parts, the main olfactory bulb (MOB) and the accessory olfactory bulb (AOB), which detect environmental odorants and pheromones, respectively. Previous studies have shown that male pheromones could stimulate neurogensis in the female AOB. Also, it could cause Bruce effect, the male-induced pregnancy block when the pregnant female is exposed to pheromones of a new male. Although the roles of pheromones in adult neurogenesis are emerging, whether they affect cell proliferation, neuronal differentiation or survival remain elusive. It is also unclear whether adult neurogenesis in the AOB is required for the formation of pheromonal memory in female mice. Therefore, the aim of this work is to study the effects of male pheromones on different aspects of AOB neurogenesis in female mice. We found that male pheromones could promote cell proliferation in SVZ and new cell survival but not neuronal differentiation of newborn cells in AOB. Moreover, survival of newborn cells was decreased when females were exposed to pheromones from a second male. Also, pheromone-induced AOB neurogenesis may be regulated by norepinephrine. In conclusion, male pheromones play important roles in adult AOB neurogenesis of female mice.

Reference ( 41 ) 〈TOP〉

Adachi K, Mirzadeh Z, Sakaguchi M, Yamashita T, Nikolcheva T, Gotoh Y, Peltz G, Gong L, Kawase T, Alvarez-Buylla A, Okano H, Sawamoto K (2007) Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone. Stem Cells 25:2827-2836.
連結：
Alonso M, Viollet C, Gabellec MM, Meas-Yedid V, Olivo-Marin JC, Lledo PM (2006) Olfactory discrimination learning increases the survival of adult-born neurons in the olfactory bulb. J Neurosci 26:10508-10513.
連結：
Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O (2002) Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 8:963-970.
連結：
Bolteus AJ, Bordey A (2004) GABA release and uptake regulate neuronal precursor migration in the postnatal subventricular zone. J Neurosci 24:7623-7631.
連結：
Brennan PA, Keverne EB (1997) Neural mechanisms of mammalian olfactory learning. Prog Neurobiol 51:457-481.
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