脈動複製器之設計、製造與測試

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脈動複製器之設計、製造與測試

The Design, Manufacturing and Testing of a Pulse Duplicator

梁逸挺 , Masters　　Advisor：陸鵬舉　　

繁體中文

順容；阻抗；脈動複製器； Compliance ； Pulse Duplicator ； Resistance

Abstract │ Reference (15) │ Times Cited (1) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

The main purpose of this present research is to design a controllable motor-driven device, named pulse duplicator, with the function of duplicating the pulsatory mechanism in the human body.   This device can be applied to evaluate the flow quality of artificial heart valves and left ventricular assist devices.  Three major components, pulse generator, resistance and compliance chamber, are combined for constructing this device.  Pulse generator can reproduce the similar pulse of natural heart, and is made up by a DC motor and a gear pump.  Compliance chamber has the function to mimic the flexibility of real blood vessel.  In this experiment, RCLRC circuit is adopted, so that there are two resistances and two compliances with fix geometric flow path are arranged.  To obtain the similar pressure wave forms in aorta and ventricle, an open loop motor controller and a close loop controller with Frank-Starling law are demonstrated in this research.  It is shown that the similar pressure wave forms in aorta and ventricle can basically be reproduced using the designed open loop controller.  However, the test result also shows that there are 200ms delay between the input commend and the actual pressure output.  In the other experiment for the close loop controller, it can be found that our system is still unable to achieve the Frank-Starling law with 100% success.  The possible reason is that our pulse generator can not provide sufficient flow rate in a very short period, and it may be caused by the pipeline too long in length on device, cause the bad low flow of high pressure.  This might be improved by shorten the length of way of equipment.

Reference ( 15 ) 〈TOP〉

1. Sharp, M. K., and Dharmalingam, R K.,“Development of a Hydraulic Model of the Human Systemic Circulation,” ASAIO Journal, vol 45, 1999, pp.535-540.
連結：
2. Suga, H., Sagawa, K., and Shoukas, A. A., “Load Independence of the Instantaneous Pressure-Volume Ratio of the Canine Left Ventricle and Effects of Epinephrine and Heart Rate on the Ratio,” Circulation Research, vol XXXII, 1973, pp314-322.
連結：
3. Ferrari, G., Lazzari, C. D., et. al.,“A Hybrid Mock Circulatory System: Testing a Prototype Under Physiologic and Pathological Conditions,” ASAIO Journal, vol 48, 2002, pp.487-494.
連結：
4. Cornhill, F., and Phil, D.,“An Aortic-Left Ventricular Pulse Duplicator Used in Testing Prosthetic Aortic Heart Valves”The journal of Thoracic and Cardiovascular Surgery, vol 73, 1977, pp.550-558.
連結：
5. Yu, Y. C., Boston, et. al.,“Pressure-Volume Relationship of Pulsatile Blood Pump for Ventricular Assist Device Development,” ASAIO Journal, vol 47, 2001, pp.293-301.
連結：

Times Cited (1) 〈TOP〉

陳耀錡(2011)。反脈動主動脈側血泵輔助下冠狀動脈相位流之離體實驗探討。成功大學航空太空工程學系學位論文。2011。1-92。

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