陰陽離子液胞包覆油/水溶性藥物之行為探討

邱文昱

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陰陽離子液胞包覆油/水溶性藥物之行為探討

Simultaneous Encapsulation of Oil-soluble and Water-soluble Drugs in Catanionic Vesicles

邱文昱 , Masters　　Advisor：楊毓民　　

繁體中文

陰陽離子界面活性劑；陰陽體；雙重包覆；物理穩定性；流動性；包覆效率；釋放速率； catanionic surfactant ； catansome ； simultaneous encapsulation ； physical stability ； fluidity ； encapsulation efficiency ； release rate

Abstract │ Reference (68) │ Times Cited (2) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

Three catanionic surfactants (DeTMA-TS , DeTMA-DS and DTMA-DS) can be made by precipitation . Catanionic vesicles can be prepared with 20v/v% ethanol by the semi-spontaneous process. A study can be tested the effects of cholesterol concentrations on the size, zeta-potential, PDI ,and physical stability in 20v/v% ethanol solution. The catansomes were used to solubilize oil-soluble drug such as vitamin E acetate and encapsulate water-soluble drug such as arbutin to test oil-soluble drug , water-soluble drug and simultaneous encapsulation on encapsulation behavior , membrane rigidity and release behavior . In addition, because structure of vitamin E acetate is similar to cholesterol , a study if vitamin E acetate act as stabilizer as cholesterol is deserved to research.
  The experimental results reveal cholesterol can stabilize the vesicle, especially for 6mM.  For drugs encapsulated catansome system, vitamin E acetate seems to act as stabilizer as cholesterol to let vesicle stable. On the contrary, arbutin can damage the stability of vesicle because it damage the attration force between head groups. As for encapsulation of oil-soluble drug , encapsulation efficiency of oil-soluble drug increased with the decrease of membrane fluidity because membrane is more hydrophobic. As for encapsulation of water-soluble drug , encapsulation efficiency of water-soluble drug increased with the increase of vesicle size due to the core volume. In addition, encapsulation efficiency of water-soluble drug increased with the decrease of membrane fluidity due to membrane permeability. Release rate of water-soluble drugs decreased with the decrease of membrane fluidity. What’s more, vitamin E acetate can stabilize vesicles without cholesterol. Therefore, vitamin E acetate can be not only encapsulater drug , but also the stabilizer.

Reference ( 68 ) 〈TOP〉

Agnihotri, S. A., Soppimath, K. S and Betageri, G. V., “Controlled release application of multilamellar vesicles: a novel drug delivery approach,” Drug Delivery, 92-101, 2010.
連結：
Atkinson, J ., Epand, R. F., Epand, R. M., “Tocopherols and tocotrienols in membranes: A critical review,” Free Radical Biology & Medicine 44, 739-746, 2008.
連結：
Bacha, D and Wachtel, E., “Phospholipid/cholesterol model membranes : formation of cholesterol crystallites,” Biochimica et Biophysica Acta 1610, 187-197, 2003.
連結：
Barry, J. A. and Gawrisch, K., “Direct NMR evidence for ethanol binding to the lipid-water interface of phospholipid bilayers,” Biochemistry 33, 8082-8088, 1994.
連結：
Benitas, S., Poly, P, A., Puisieux, F., and Delattre, J., “Radiopaque liposomes: effect of formulation conditions on encapsulation efficiency,” Journal of Pharmaceutical Sciences, 73, 1751-1755,1984.
連結：

Times Cited (2) 〈TOP〉

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